广西医学
廣西醫學
엄서의학
GUANGXI MEDICAL JOURNAL
2014年
6期
780-782
,共3页
李无名%唐柳生%李勇%黄碧琳%卢瑞朝
李無名%唐柳生%李勇%黃碧琳%盧瑞朝
리무명%당류생%리용%황벽림%로서조
结核病%结核分枝杆菌%耐药%肺结核
結覈病%結覈分枝桿菌%耐藥%肺結覈
결핵병%결핵분지간균%내약%폐결핵
Tuberculosis%Mycobacterium tuberculosis%Drug resistance%Pulmonary tuberculosis
目的：了解结核病患者的耐药情况，为制订合理的治疗方案提供参考。方法分析1067例结核病患者的临床资料及其药敏结果。结果1067例患者中全敏感792例，耐药275例（25．77％），其中单耐药98例（9．18％），多耐药48例（4．50％），耐多药117例（10．97％），广泛耐药12例（1．12％）。复治患者耐药率明显高于初治患者（P＜0．05），HIV抗体阳性患者耐药率与HIV抗体阴性患者比较，差异无统计学意义（P＞0．05）。在耐药患者中，67．64％对异烟肼耐药，65．09％对利福平耐药。氧氟沙星的总耐药率9．18％，而单耐药率2．34％。耐多药占耐药患者42．55％，以耐异烟肼、利福平最常见。结论结核病专科医院患者结核分枝杆菌耐药率较高，耐药谱多样，以耐异烟肼、利福平最常见。
目的：瞭解結覈病患者的耐藥情況，為製訂閤理的治療方案提供參攷。方法分析1067例結覈病患者的臨床資料及其藥敏結果。結果1067例患者中全敏感792例，耐藥275例（25．77％），其中單耐藥98例（9．18％），多耐藥48例（4．50％），耐多藥117例（10．97％），廣汎耐藥12例（1．12％）。複治患者耐藥率明顯高于初治患者（P＜0．05），HIV抗體暘性患者耐藥率與HIV抗體陰性患者比較，差異無統計學意義（P＞0．05）。在耐藥患者中，67．64％對異煙肼耐藥，65．09％對利福平耐藥。氧氟沙星的總耐藥率9．18％，而單耐藥率2．34％。耐多藥佔耐藥患者42．55％，以耐異煙肼、利福平最常見。結論結覈病專科醫院患者結覈分枝桿菌耐藥率較高，耐藥譜多樣，以耐異煙肼、利福平最常見。
목적：료해결핵병환자적내약정황，위제정합리적치료방안제공삼고。방법분석1067례결핵병환자적림상자료급기약민결과。결과1067례환자중전민감792례，내약275례（25．77％），기중단내약98례（9．18％），다내약48례（4．50％），내다약117례（10．97％），엄범내약12례（1．12％）。복치환자내약솔명현고우초치환자（P＜0．05），HIV항체양성환자내약솔여HIV항체음성환자비교，차이무통계학의의（P＞0．05）。재내약환자중，67．64％대이연정내약，65．09％대리복평내약。양불사성적총내약솔9．18％，이단내약솔2．34％。내다약점내약환자42．55％，이내이연정、리복평최상견。결론결핵병전과의원환자결핵분지간균내약솔교고，내약보다양，이내이연정、리복평최상견。
Objective To explore the situation of drug resistance in tuberculosis (TB) patients,and to provide the references for formulating a reasonable therapy .Methods A clinical data of 1067 TB patients and their drug susceptibility test results were analyzed.Results Among 1 067 cases,there were 792 sensitive cases,275(25.77%) drug resistant cases, including 98 (9.18%) of mono-resistance,48 (4.50%) of poly-resistance,117 (10.97%) of multidrug-resistance,12 (1.12%) of extensively drug-resistance.The drug resistance rate of re-treatment patients was significantly higher than that of first-treatment patients(P<0.05).There was no significant difference in the drug resistance rate between patients with positive HIV antibody and patients with negative HIV antibody (P>0.05).67.64% of the drug resistant patients had isoniazid resistance ,65.09%of the drug resistant patients had rifampicin resistance .The total rate of drug resistance of ofloxacin was 9.18%,and mono-resistance rate was 2.34%.Multidrug-resistance accounted for 42.55%of patients with drug resistance ,the resistances to isoniazid and rifampicin were the most common .Conclusion The patients in the tuberculosis special hospital have a higher mycobacterium tuberculosis resistance rate and various drug resistance pro -files,the resistances to isoniazid and rifampicin are the most common .
