中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
2期
179-181
,共3页
放射治疗%替吉奥%食管肿瘤%老年人
放射治療%替吉奧%食管腫瘤%老年人
방사치료%체길오%식관종류%노년인
Radiotherapy%S-1%Esophageal neoplasms%Aged
目的 探讨三维适形放疗联合替吉奥同步化疗治疗老年人食管癌的近期疗效及毒副反应.方法 将80例老年食管癌患者采用数字表法随机分为对照组和联合组各40例.两组均采用三维适形放射治疗,处方剂量为60～64 Gy/30～32 f.联合组于放疗第1天联合替吉奥同步化疗,具体为:替吉奥80 mg/m2,分早、晚餐后两次服用,第1 ～ 14天,21 d为1周期,共2个周期.结果 联合组总有效率(CR+PR)为87.5％,单放组总有效率(CR+ PR)为62.5％,两组差异具有统计学意义(x2=6.667,P=0.01)；而一年总生存率(OS)分别为77.7％和57.5％,差异无统计学意义(P=0.056).联合组骨髓抑制不良反应较单放组增加,但经处理后均能顺利完成治疗.结论 三维适形放疗联合替吉奥同步化疗治疗老年人食管癌较单纯放疗近期疗效显著提高,毒副反应可以耐受,该方案的远期疗效有待进一步观察.
目的 探討三維適形放療聯閤替吉奧同步化療治療老年人食管癌的近期療效及毒副反應.方法 將80例老年食管癌患者採用數字錶法隨機分為對照組和聯閤組各40例.兩組均採用三維適形放射治療,處方劑量為60～64 Gy/30～32 f.聯閤組于放療第1天聯閤替吉奧同步化療,具體為:替吉奧80 mg/m2,分早、晚餐後兩次服用,第1 ～ 14天,21 d為1週期,共2箇週期.結果 聯閤組總有效率(CR+PR)為87.5％,單放組總有效率(CR+ PR)為62.5％,兩組差異具有統計學意義(x2=6.667,P=0.01)；而一年總生存率(OS)分彆為77.7％和57.5％,差異無統計學意義(P=0.056).聯閤組骨髓抑製不良反應較單放組增加,但經處理後均能順利完成治療.結論 三維適形放療聯閤替吉奧同步化療治療老年人食管癌較單純放療近期療效顯著提高,毒副反應可以耐受,該方案的遠期療效有待進一步觀察.
목적 탐토삼유괄형방료연합체길오동보화료치료노년인식관암적근기료효급독부반응.방법 장80례노년식관암환자채용수자표법수궤분위대조조화연합조각40례.량조균채용삼유괄형방사치료,처방제량위60～64 Gy/30～32 f.연합조우방료제1천연합체길오동보화료,구체위:체길오80 mg/m2,분조、만찬후량차복용,제1 ～ 14천,21 d위1주기,공2개주기.결과 연합조총유효솔(CR+PR)위87.5％,단방조총유효솔(CR+ PR)위62.5％,량조차이구유통계학의의(x2=6.667,P=0.01)；이일년총생존솔(OS)분별위77.7％화57.5％,차이무통계학의의(P=0.056).연합조골수억제불량반응교단방조증가,단경처리후균능순리완성치료.결론 삼유괄형방료연합체길오동보화료치료노년인식관암교단순방료근기료효현저제고,독부반응가이내수,해방안적원기료효유대진일보관찰.
Objective To evaluate the efficacy and safety of S-1 combined with synchronous three-dimensional conformal radiotherapy in the treatment of elderly patients with esophageal cancer.Methods 80 elderly patients with esophageal cancer were randomly divided into control group and the combination group,40 cases in each group.Three-dimensional conformal radiotherapy was applied in the two groups with a total dose of DT 60-64 Gy/ 30-32f.Patients in the combination group received S-1 chemotherapy concurrent with the radiotherapy on the first day.S-1 was orally given 80mg/m2 daily after meals from d1 to d14,21 days as a cycle and treated for 2 cycles.Results The total effective rate (CR + PR) of the combination group was 87.5％,that was 62.5％ of the control group,and there was statistically significant difference between the two groups (x2 =6.667,P =0.01).The one year overall survival rate of the two groups was 77.5 ％ and 57.5 ％,respectively,the difference was not significant (P =0.056).The incidence rate of hematological toxicity was higher in the combination group than that in the control group,but the toxic reaction was mild and tolerable.Conclusion The short-term curative effect of S-1 combined with three-dimensional conformal radiotherapy is feasible for elderly patients with esophageal cancer,and the toxicity is tolerable.
