CAJ | 학술논문

在PICU中实施恰当的镇痛镇静可改善患儿的生命质量,避免常见的ICU治疗不良反应.针对每一例患儿均需制定个体化镇痛镇静计划、定期评估镇痛镇静效果并及时调整治疗计划.本文系统介绍了目前我国PICU常用镇痛镇静药物的特点及使用方法,并对一些可能具有应用前景的药物亦作了简单介绍.同时,本文还对镇痛镇静过程中可能出现的不良反应及其预防治疗措施作了系统的阐述.
재PICU중실시흡당적진통진정가개선환인적생명질량,피면상견적ICU치료불량반응.침대매일례환인균수제정개체화진통진정계화、정기평고진통진정효과병급시조정치료계화.본문계통개소료목전아국PICU상용진통진정약물적특점급사용방법,병대일사가능구유응용전경적약물역작료간단개소.동시,본문환대진통진정과정중가능출현적불량반응급기예방치료조시작료계통적천술.
Almost all children in PICU need analgesia and/or sedation.A therapeutic plan for analgesia and sedation should be established for each patient and regularly reviewed.The most often used sedation agents in PICU patients are Morphine or Fentanyl alone or in combination with Midazolam.There are several agents that have been used to provide sedation and analgesia in the PICU patient including benzodiazepines,opioids,ketamine,propofol,chloral hydrate,barbiturates,NSAIDs and paracetamol and α-adrenoreceptor agonists.This review described the various agents for sedation and discussed their advantages and disadvantages as they pertain to the PICU.Consequences of and treatment strategies for adverse effects with sedation and analgesia including respiratory depression,hypotension,withdrawal syndrome and propofol infusion syndrome were reviewed.