CAJ | 학술논문

目的：探讨美罗培南在治疗老年重症院内获得性肺炎中的疗效。方法随机选取我科老年重症肺炎患者189例，其中73例作为病例组采用美罗培南静脉注射治疗，美罗培南治疗方法和剂量为静脉滴注500 mg/次，每日3次；而116例设为对照组，使用亚胺培南-西司他丁静脉滴注500 mg/次，每日4次。疗程均为7~10 d。分析两组的临床疗效、细菌清除情况、不良反应。结果治疗组总有效率82．19%，细菌清除率87．93%，不良反应发生率5．48%；对照组总有效率为62．93%，细菌清除率68．35%，不良反应发生率6．03%。美罗培南组总有效率、细菌清除率均高于对照组，差异均有统计学意义( P<0．05)。结论美罗培南更适用于老年重症院内获得性肺炎、老年重症感染、和或伴有中枢神经精神症状者的患者。
목적：탐토미라배남재치료노년중증원내획득성폐염중적료효。방법수궤선취아과노년중증폐염환자189례，기중73례작위병례조채용미라배남정맥주사치료，미라배남치료방법화제량위정맥적주500 mg/차，매일3차；이116례설위대조조，사용아알배남-서사타정정맥적주500 mg/차，매일4차。료정균위7~10 d。분석량조적림상료효、세균청제정황、불량반응。결과치료조총유효솔82．19%，세균청제솔87．93%，불량반응발생솔5．48%；대조조총유효솔위62．93%，세균청제솔68．35%，불량반응발생솔6．03%。미라배남조총유효솔、세균청제솔균고우대조조，차이균유통계학의의( P<0．05)。결론미라배남경괄용우노년중증원내획득성폐염、노년중증감염、화혹반유중추신경정신증상자적환자。
Objective To investigate the efficacy of meropenem in the treatment of elderly patients with se-vere hospital acquired pneumonia. Methods 189 elderly patients with severe pneumonia were randomly divided into two groups. The treatment group was given intravenous injection with meropenem, 500 mg/once, three times a day. The control group was given imipenem cilastatin intravenous, 500 mg/once, four times a day. The clinical curative effect was evaluated between the two groups. Results The total effective rate of the treatment group was 82. 19%, the bacterial clearance rate was 87. 93%, and the incidence of adverse reaction was 5. 48%. The total effective rate was 62. 93% in the control group, the bacterial clearance rate was 68. 35%, and the incidence of adverse reaction was 6. 03%. Conclusion Meropenem is more suitable for the elderly patients with severe hospital-acquired pneumo-nia, and severe infection associated with central nervous mental symptoms.