CAJ | 학술논문

目的：探讨儿童社区获得性耐甲氧西林金黄色葡萄球菌脓毒症的临床特点。方法回顾性分析该院重症监护中心2012年1月-2013年12月收治的11例耐甲氧西林金葡菌脓毒症的发病情况及临床特点。结果11例儿童发病前均系健康儿童；突发起病，分别以毒血症状（11例）、皮肤及软组织感染（10例）、脓毒性休克（5例）、坏死性肺炎（3例）为主要表现，疾病进展迅速。药敏显示，社区获得性耐甲氧西林金葡菌对万古霉素、利奈唑胺均敏感，对红霉素100％耐药，对克林霉素90．1％耐药。结论耐甲氧西林金葡菌脓毒症在儿童社区获得性感染中占有一定比例，具有一定的特征，皮肤软组织感染多见，出现坏死性肺炎预后欠佳。早期发现及时治疗是治愈的关键。
목적：탐토인동사구획득성내갑양서림금황색포도구균농독증적림상특점。방법회고성분석해원중증감호중심2012년1월-2013년12월수치적11례내갑양서림금포균농독증적발병정황급림상특점。결과11례인동발병전균계건강인동；돌발기병，분별이독혈증상（11례）、피부급연조직감염（10례）、농독성휴극（5례）、배사성폐염（3례）위주요표현，질병진전신속。약민현시，사구획득성내갑양서림금포균대만고매소、리내서알균민감，대홍매소100％내약，대극림매소90．1％내약。결론내갑양서림금포균농독증재인동사구획득성감염중점유일정비례，구유일정적특정，피부연조직감염다견，출현배사성폐염예후흠가。조기발현급시치료시치유적관건。
Objective To explore the clinical characteristics of children with sepsis caused by community-acquired methicillin-resistant staphylococcus aureus (CA-MRSA).Methods The clinical data of 1 1 cases with CA-MRSA were analyzed retrospectively from Anhui Provincial Children’s Hospital during Jan 2012 to Dec 2013.Results There were eleven cases of toxemic symptoms,10 cases of skin and soft tissue infection,5 cases of septic shock,and 3 cases of necrotizing pneumonia.Disease progression was rapid,and the culture positive rate with blood or exudation was high.The susceptibility tests showed CA-MRSA was susceptible to vancomycin,linezolid,re-sistant to erythromycin and clindamycin.Three cases died of the infection of CA-MRSA.Conclusions The sepsis caused by communi-ty-acquired methicillin-resistant staphylococcus aureus in children should be recognized,which were mostly infection in skin and soft tissue and had poor prognosis in necrotizing pneumonia.So early detection and early intervention is the key to the treatment.