CAJ | 학술논문

目的：评价乐卡地平与培哚普利小剂量单独治疗和联合治疗轻度原发性高血压的疗效及安全性。方法180例轻度原发性高血压患者随机分成联合治疗组（A组）和单用乐卡地平组（B组）和单用培哚普利组（C组）。A组服用培哚普利2 mg· d-1＋乐卡地平5 mg·d-1；B组服用乐卡地平10 mg·d-1；C组服用培哚普利4 mg·d-1。分别观察三组治疗后4、8、12周后降压效果及安全性。结果联合治疗组第4周开始，血压达标率及血压下降幅度均优于单药治疗组，三组间差异有统计学意义（P＜0．05）。联合治疗组治疗期间不良事件发生4例，明显低于单药治疗组（乐卡地平组7例，培哚普利组19例），差异有显著性（P＜0．05）。结论乐卡地平与培哚普利联合应用可明显增加降压幅度和降压速度、提高降压有效率，两药小剂量联合可减少药物不良反应发生率。
목적：평개악잡지평여배타보리소제량단독치료화연합치료경도원발성고혈압적료효급안전성。방법180례경도원발성고혈압환자수궤분성연합치료조（A조）화단용악잡지평조（B조）화단용배타보리조（C조）。A조복용배타보리2 mg· d-1＋악잡지평5 mg·d-1；B조복용악잡지평10 mg·d-1；C조복용배타보리4 mg·d-1。분별관찰삼조치료후4、8、12주후강압효과급안전성。결과연합치료조제4주개시，혈압체표솔급혈압하강폭도균우우단약치료조，삼조간차이유통계학의의（P＜0．05）。연합치료조치료기간불량사건발생4례，명현저우단약치료조（악잡지평조7례，배타보리조19례），차이유현저성（P＜0．05）。결론악잡지평여배타보리연합응용가명현증가강압폭도화강압속도、제고강압유효솔，량약소제량연합가감소약물불량반응발생솔。
Objective To investigate the efficacy and safety of combination of perindopril and lercanidipine comparing with perindopril or lercanidipine only for mild essential hypertensive patients.Methods A hundred and eighty patients with mild essential hypertension were randomized into three groups:group A (perindopril 2 mg·d-1 plus lercanidipine 5 mg·d-1 ),group B (lercanidipine 10 mg· d-1 )and group C (perindopril 4 mg·d-1 ).The efficacy of treatment and adverse effects were evaluated at the end of 4,8 and 12 weeks after treatment.Results The blood pressure in group A was lower than that in group B and group C at the end of 4 weeks after treatment.Compared with group B and group C,the reaching target blood pressure rate was better in group A.Differences had statistical meaning at the end of 8 weeks among three groups (P<0.05).There were 4 cases of ADR in group A,which is significantly lower than that in group B (7 cases)and in group C (19 cases).There were significant differences in adverse reaction among three groups.Con-clusions Low-dose combination of lercanidipine and perindopril is effective and safe in the treatment of mild hypertension.