CAJ | 학술논문

目的：研究人类表皮生长因子受体-2（HER-2）在大肠癌患者中的表达及特征，了解其与患者预后的相关性。方法采用免疫组化法检测121例大肠癌组织及66例正常大肠组织中HER-2的表达情况，比较大肠癌组织中不同的病理特征和临床资料与HER-2表达的相关性。结果正常组织中HER-2表达阳性12例（18．2％），大肠癌组织中阳性46例（38．0％），两组比较差异有统计学意义（P＜0．05）；HER-2的表达与年龄、性别、肿瘤直径和部位、远端转移无关（P＞0．05），与分化程度、分期、淋巴结转移有明显的相关性（P＜0．05）。HER-2高表达的大肠癌患者5年生存率低于低表达患者（P＜0．05）。结论HER-2的表达与大肠癌的发生有关，可以作为早期检测及评价预后的标志。
목적：연구인류표피생장인자수체-2（HER-2）재대장암환자중적표체급특정，료해기여환자예후적상관성。방법채용면역조화법검측121례대장암조직급66례정상대장조직중HER-2적표체정황，비교대장암조직중불동적병리특정화림상자료여HER-2표체적상관성。결과정상조직중HER-2표체양성12례（18．2％），대장암조직중양성46례（38．0％），량조비교차이유통계학의의（P＜0．05）；HER-2적표체여년령、성별、종류직경화부위、원단전이무관（P＞0．05），여분화정도、분기、림파결전이유명현적상관성（P＜0．05）。HER-2고표체적대장암환자5년생존솔저우저표체환자（P＜0．05）。결론HER-2적표체여대장암적발생유관，가이작위조기검측급평개예후적표지。
Objective To investigate the expression of HER-2 in patients with colorectal cancer and the relationship between its expres-sion and patients,prognosis.Methods Immunohistochemistry was used to detect the expression of HER-2 in 121 cases of colorectal cancer tissue and 66 cases of normal colorectal tissue.Pathological characteristics and clinical data were compared between those two groups.Results HER-2 was positively expressed in 12 cases (18.2%)of normal tissue and 46 cases (38.0%)of colorectal cancer tissue,and the difference was statistically significant (P<0.05).The overexpression of HER-2 was not associated with patients,age, gender,tumor size,location and distant metastases (P>0.05 ),but associated with differentiation stage,Dukes, stage and lymphatic metastases (P<0.05 ).The colorectal cancer patients with overexpression of HER-2 had a significantly lower five-year survival than those with low expression (P<0.05).Conclusions The expression of HER-2 was associated with the occurrence of colorectal cancer, which could be used as a marker for early detection and prognosis.