CAJ | 학술논문

目的：探讨非小细胞肺癌（non-small cell lung cancer，NSCLC）患者应用立体定向放疗对其复发率与远处转移率的影响。方法选取在暨南大学附属第一医院就诊的非小细胞肺癌患者104例，随机分为立体定向放疗组和常规放疗组，每组各52例。立体定向放疗组患者采用立体定向放疗进行治疗，常规放疗组采用常规分割照射进行治疗。患者随访3年，死亡病例依据死亡原因纳入统计。统计患者的近期疗效与放疗后1、2、3年的复发率和转移率。结果立体定向放疗组获得了较高的完全缓解（CR）率和较低的进展（PD）率。立体定向放疗组的有效率（80．77％）与放疗后常规放疗组（51．92％）比较，P＜0．05，差异具有统计学意义；立体定向放疗组患者1、2、3年的复发率和转移率与同时间段的常规放疗组比较，P＜0．05，差异具有统计学意义。结论非小细胞肺癌患者应用立体定向放疗可以获得较好的完全缓解率，有效的控制了复发与远处转移的发生。
목적：탐토비소세포폐암（non-small cell lung cancer，NSCLC）환자응용입체정향방료대기복발솔여원처전이솔적영향。방법선취재기남대학부속제일의원취진적비소세포폐암환자104례，수궤분위입체정향방료조화상규방료조，매조각52례。입체정향방료조환자채용입체정향방료진행치료，상규방료조채용상규분할조사진행치료。환자수방3년，사망병례의거사망원인납입통계。통계환자적근기료효여방료후1、2、3년적복발솔화전이솔。결과입체정향방료조획득료교고적완전완해（CR）솔화교저적진전（PD）솔。입체정향방료조적유효솔（80．77％）여방료후상규방료조（51．92％）비교，P＜0．05，차이구유통계학의의；입체정향방료조환자1、2、3년적복발솔화전이솔여동시간단적상규방료조비교，P＜0．05，차이구유통계학의의。결론비소세포폐암환자응용입체정향방료가이획득교호적완전완해솔，유효적공제료복발여원처전이적발생。
Objective To investigate stereotactic radiotherapy effects on recurrence rate and distant metastasis rate of non-small cell lung cancer(NSCLC)patients.Methods A hundred and four patients with non-small cell lung cancer treated at The Sixth Hospital Affiliated to Zhongshan University were randomized into stereotactic radiotherapy group (n=52)and conventional radiotherapy group (n=52).Stereotactic radiotherapy group was treated with stereotactic radiotherapy,while conventional radiotherapy group with conven-tional fractionated irradiation.The patients were followed up for 3 years,and the death cases were included into statistics based on cau-ses.Short-term efficacy,recurrence rate and distant metastasis rates after 1 year,2 years,3 years were observed.Results Stereotactic radiotherapy group had a higher CR rate and lower PD rate.The effective rate in stereotactic radiotherapy group is significantly different from that in conventional radiotherapy group (80.77%vs 51.92%,P<0.05).One-year,2-year,3-year recurrence rate and distant me-tastasis rate in stereotactic radiotherapy group were significantly different from those in conventional radiotherapy group (P<0.05 ). Conclusions The application of stereotactic radiotherapy on non-small cell lung cancer can get a better complete remission rate,which can effectively control the recurrence and distant metastasis.