CAJ | 학술논문

目的：探讨体外受精-胚胎移植（IVF-ET）过程中影响妊娠结局的主要临床因素。方法选取2012年1-12月在合肥市某生殖中心进行IVF-ET的不孕症患者1742例，查看IVF登记本，对不孕症妇女临床资料进行回顾性收集，应用SPSS软件进行统计分析。结果在1742个周期中共获卵母细胞25923个，受精19909个，受精率76．80％；卵裂19749个，卵裂率99．20％；临床妊娠623例，临床妊娠率35．76％。随着年龄增加，获卵数逐渐减少，各年龄组（≤35岁、36～40岁、＞40岁三组）的获卵数、受精率差异有显著性（P＜0．05），临床妊娠率随年龄增大有下降趋势，＞40岁组的临床妊娠率为8．93％，显著低于其他组（P＜0．05）；随着获卵数增加，临床妊娠率呈上升趋势（P＜0．05）；两种不孕类型间临床妊娠率差异无统计学意义（P＞0．05）；与不孕年限≤10年组相比，不孕年限＞10年组的临床妊娠率显著下降，且两组间差异有统计学意义（P＜0．05）。结论年龄、不孕年限及获卵数是影响女性IVF-ET成功率的重要因素。
목적：탐토체외수정-배태이식（IVF-ET）과정중영향임신결국적주요림상인소。방법선취2012년1-12월재합비시모생식중심진행IVF-ET적불잉증환자1742례，사간IVF등기본，대불잉증부녀림상자료진행회고성수집，응용SPSS연건진행통계분석。결과재1742개주기중공획란모세포25923개，수정19909개，수정솔76．80％；란렬19749개，란렬솔99．20％；림상임신623례，림상임신솔35．76％。수착년령증가，획란수축점감소，각년령조（≤35세、36～40세、＞40세삼조）적획란수、수정솔차이유현저성（P＜0．05），림상임신솔수년령증대유하강추세，＞40세조적림상임신솔위8．93％，현저저우기타조（P＜0．05）；수착획란수증가，림상임신솔정상승추세（P＜0．05）；량충불잉류형간림상임신솔차이무통계학의의（P＞0．05）；여불잉년한≤10년조상비，불잉년한＞10년조적림상임신솔현저하강，차량조간차이유통계학의의（P＜0．05）。결론년령、불잉년한급획란수시영향녀성IVF-ET성공솔적중요인소。
Objective To study the main clinical factors which impact pregnant outcome during in-vitro fertilization and embryo transfer (IVF-ET)process.Methods A total of 1 742 infertility patients undergoing IVF-ET in a reproductive center were enrolled in Hefei from Jan 2012 to Dec 2012,whose clinical data were retrospectively collected by consulting the IVF register and analyzed by SPSS soft-ware.Results In the 1 742 cycles ,25 923 oocytes were collected,19 909 of which were fertilized with a fertilization rate of 76.80%;among them,19 749 zygotes turned cleavage with a cleavage rate of 99.20%;623 cases got clinical pregnant with the pregnancy rate of 35 .76%.With the increase of age,the number of retrieved oocytes decreased.The number of oocytes and fertilization rate of each age group(≤35,36 ~40,>40)had significant differences (P<0.05).The clinical pregnancy rate had a negative relationship with age and clinical pregnancy rate of the age group of >40 was significantly lower than the other groups (P<0.05 );clinical pregnancy rate gradually increased with the number of retrieved oocytes (P<0.05);infertility clinical pregnancy rates of the two types had no statisti-cal significance(P>0.05);the clinical pregnancy rate of the group which infertility duration ≤10 years was significantly lower than the group >10 years(P<0.05).Conclusions Age,duration of infertility and the number of retrieved oocytes are prominent factors which affect female pregnancy rate in IVF-ET programs.