CAJ | 학술논문

目的：观察保心康（BXK）对异丙肾上腺素（ISO）所致大鼠急性心肌缺血的保护作用。方法采用改良的Rona法复制大鼠急性心肌缺血模型，检测大鼠心电图（ECG）改变及血清中超氧化物歧化酶（SOD）活性、丙二醛（MDA）、乳酸（LD）、乳酸脱氢酶（LDH）以及肌酸磷酸激酶（CPK）含量，测定心肌含水量以及观察心肌组织病理改变。结果与心肌缺血模型组比较， BXK（18、36 mg·kg-1）可显著改善心肌缺血大鼠心电图S-T段抬高，明显提高心肌缺血大鼠血清中SOD活性，降低MDA含量，降低LD，LDH和CPK含量。BXK（18、36 mg·kg-1）能够不同程度减少心肌含水量及心肌缺血大鼠心肌组织病理损伤。结论保心康对大鼠急性心肌缺血模型具有明显的保护作用。
목적：관찰보심강（BXK）대이병신상선소（ISO）소치대서급성심기결혈적보호작용。방법채용개량적Rona법복제대서급성심기결혈모형，검측대서심전도（ECG）개변급혈청중초양화물기화매（SOD）활성、병이철（MDA）、유산（LD）、유산탈경매（LDH）이급기산린산격매（CPK）함량，측정심기함수량이급관찰심기조직병리개변。결과여심기결혈모형조비교， BXK（18、36 mg·kg-1）가현저개선심기결혈대서심전도S-T단태고，명현제고심기결혈대서혈청중SOD활성，강저MDA함량，강저LD，LDH화CPK함량。BXK（18、36 mg·kg-1）능구불동정도감소심기함수량급심기결혈대서심기조직병리손상。결론보심강대대서급성심기결혈모형구유명현적보호작용。
Objective To observe the effect of Baoxinkang(BXK)on isoprenaline (ISO)-induced acute myocardial ischemia(AMI). Methods Acute myocardial ischemia rats model was established by subcutaneous injection of ISO.Electro-cardiogram (ECG)was ob-served.Super oxide dismutase (SOD)activity,the contents of malondialdehyde (MDA)and lactic acid(LD)as well as lactate dehydro-genase (LDH)in the myocardial homogenate and creatine phosphokinase (CPK)were observed after ISO subcutaneous injection.Myo-cardial water contents were determined and pathological changes of myocardial tissue were observed.Results Compared with the model group,BXK(18、36 mg·kg-1 )could significantly improve the ECG S-T segment elevation of myocardial ischemia in rats,increase SOD activity,decrease contents of MDA and LD and LDH.It could also decrease contents of CPK.BXK(18、36 mg·kg-1 )could reduce my-ocardial water content and pathological changes of myocardial.The result has statistical significance.Conclusion BXK has therapeutic effect on ISO-induced myocardial ischemia injury.