CAJ | 학술논문

目的：探讨右美托咪啶在预防全麻术后躁动和咽喉疼痛方面的应用价值，以提高全身麻醉的安全性。方法选取接受全麻手术治疗的患者114例，通过随机数字表法将其分为观察组和对照组各57例。两组均采用相同的药物进行全身麻醉，观察组在手术结束前半个小时静脉泵入右美托咪啶，对照组则静脉泵入相同体积的0.9％氯化钠注射液。对比两组患者恢复自主呼吸的时间和拔除气管插管时间以及术后躁动和咽喉疼痛的发生率。结果两组患者恢复自主呼吸时间、拔除气管插管时间的对比，差异无统计学意义（ P ﹥0.05）。在术后躁动方面，观察组0级的有53例，躁动率为7.02％；对照组0级的有34例，躁动率为40.35％。观察组躁动率显著低于对照组（ P ﹤0.05）。在术后咽喉疼痛方面，观察组0级的有46例，咽喉疼痛率为19.30％；对照组0级的有30例，咽喉疼痛率为47.37％。观察组咽喉疼痛率显著低于对照组（ P ﹤0.05）。结论右美托咪啶对全麻术后躁动和咽喉疼痛具有良好的预防作用，同时不会增加呼吸抑制的风险，值得在临床上推广应用。
목적：탐토우미탁미정재예방전마술후조동화인후동통방면적응용개치，이제고전신마취적안전성。방법선취접수전마수술치료적환자114례，통과수궤수자표법장기분위관찰조화대조조각57례。량조균채용상동적약물진행전신마취，관찰조재수술결속전반개소시정맥빙입우미탁미정，대조조칙정맥빙입상동체적적0.9％록화납주사액。대비량조환자회복자주호흡적시간화발제기관삽관시간이급술후조동화인후동통적발생솔。결과량조환자회복자주호흡시간、발제기관삽관시간적대비，차이무통계학의의（ P ﹥0.05）。재술후조동방면，관찰조0급적유53례，조동솔위7.02％；대조조0급적유34례，조동솔위40.35％。관찰조조동솔현저저우대조조（ P ﹤0.05）。재술후인후동통방면，관찰조0급적유46례，인후동통솔위19.30％；대조조0급적유30례，인후동통솔위47.37％。관찰조인후동통솔현저저우대조조（ P ﹤0.05）。결론우미탁미정대전마술후조동화인후동통구유량호적예방작용，동시불회증가호흡억제적풍험，치득재림상상추엄응용。
Objective Toexploretheapplicationvalueofdexmedetomidineinreducingagitationandthroatpainaftergeneralanesthesia, inordertoimprovethesafetyofanesthesia.Methods Atotalof114patientsunderwentgeneralanesthesiaforoperationinthishospitalwerese-lected for this study,they were divided by random number table method into observation group and control group,each with 57 cases. Patients in these two groups were used with same drug for general anesthesia,patients in observation group were given with intravenous infusion of dexmedeto-midine at half hour before the end of operation,while patients in control group were administrated with intravenous infusion of same volume of 0. 9% sodium chloride solution. The incidence rates of agitation,spontaneous breathing recovery time,extubation time and postoperative sore throat werecomparedbetweenbothgroups.Results Therestorationofspontaneousbreathingtimeandextubationtimehadbeencomparedbetweenthese two groups,the difference was not statistically significant( P ﹥0. 05). In postoperative agitation,53 cases in observation group with grade 0,agi-tation rate was 7. 02%;and 34 patients in control group with grade 0,the agitation rate was 40. 35%. Agitation in observation group was signifi-cantly lower than that of control group( P ﹤0. 05). In postoperative sore throat,46 cases in observation group with grade 0,rate of throat pain was 19. 30%;and 30 cases in control group with grade 0,throat pain rate was 47. 37%. The rate of throat pain in observation group was signifi-cantlylowerthanthatofcontrolgroup(P﹤0.05).Conclusion Dexmedetomidinehasagoodpreventiveeffectonagitationandthroatpainafter general anesthesia,and it also does not increase the risk of respiratory depression,hence it is worthy to be used for clinical application.