CAJ | 학술논문

目的：评价γ干扰素释放试验（IGRA）对早期肺结核的诊断价值。方法选取2012年1月至2013年1月初诊疑似为肺结核患者68例（观察组），以及健康体检者30例（对照组），行 IGRA 和结核菌素试验（TST）。结果通过 IGRA，68例疑似患者治疗前的阳性率为88.2％，明显高于治疗后的7.4％以及对照组的3.3％，差异有统计学意义（ P ﹤0.05）；通过与金标准比较，IGRA 诊断早期肺结核总的灵敏度为90.3％（56/62），特异度为66.7％（4/6），准确性为88.2％（60/68），阳性预测值为94.9％（56/59），阴性预测值为66.6％（6/9）。结论γ干扰素释放试验诊断早期肺结核的敏感度好，特异度高，可适用于老龄患者以及低龄患儿，有助于活动性肺结核的早期快速诊断。
목적：평개γ간우소석방시험（IGRA）대조기폐결핵적진단개치。방법선취2012년1월지2013년1월초진의사위폐결핵환자68례（관찰조），이급건강체검자30례（대조조），행 IGRA 화결핵균소시험（TST）。결과통과 IGRA，68례의사환자치료전적양성솔위88.2％，명현고우치료후적7.4％이급대조조적3.3％，차이유통계학의의（ P ﹤0.05）；통과여금표준비교，IGRA 진단조기폐결핵총적령민도위90.3％（56/62），특이도위66.7％（4/6），준학성위88.2％（60/68），양성예측치위94.9％（56/59），음성예측치위66.6％（6/9）。결론γ간우소석방시험진단조기폐결핵적민감도호，특이도고，가괄용우노령환자이급저령환인，유조우활동성폐결핵적조기쾌속진단。
Objective To perform an analysis on the clinical effect of IGRA in diagnosis of pulmonary tuberculosis. Methods 68 pa-tients diagnosis with pulmonary tuberculosis were chosen as the observation group during January 2012 to January 2013,while 30 healthy people were chosen to be the control group in the same time. The patients of 2 groups were both taken IGRA experiment and TST. Results The positive rate of observation group before treatment was 88. 2% ,which was much higher than that after treatment(7. 4% )and the control group(3. 3% ). The difference is significant. The sensitivity was 90. 3%(56 / 62),and the specification was 66. 7%(4 / 6). The accuracy was 88. 2%(60 / 68), while the positive expectation rate was 94. 9%(56 / 59). The negative expectation rate was 66. 6%(6 / 9). Conclusion IGRA can diagnose early pulmonary tuberculosis with good sensitivity and accuracy. This method is worthy to used in elderly patients and children. It can improve the diag-nosis race of active pulmonary tuberculosis.