CAJ | 학술논문

目的：探讨和分析小剂量胺碘酮联合倍他乐克治疗肥厚型心肌病伴恶性室性心律失常治疗中的临床效果。方法将94例肥厚型心肌病伴恶性室性心律失常患者按照住院时间先后顺序分组为对照组和观察组；对照组：采用倍他乐克治疗；观察组：采用小剂量胺碘酮联合倍他乐克治疗。对两组患者进行为期6~12个月随访。结果观察组和对照组的治疗有效率分别为95.7％（45/47）、80.9％（38/47）。除 QT 间期最大值以外，两组心电图指标和 LVEF 治疗后均较治疗前显著改善（ P ﹤0.05），观察组治疗后心率和 QT 间期最小值以及 QT 散度、LVEF、再住院率、猝死率等方面均优于对照组（ P ﹤0.05）。治疗和随访期间均没有发现明显性不良反应。结论采用小剂量胺碘酮联合倍他乐克治疗肥厚型心肌病伴恶性室性心律失常，可有效地改善患者的临床症状，效果明确。
목적：탐토화분석소제량알전동연합배타악극치료비후형심기병반악성실성심률실상치료중적림상효과。방법장94례비후형심기병반악성실성심률실상환자안조주원시간선후순서분조위대조조화관찰조；대조조：채용배타악극치료；관찰조：채용소제량알전동연합배타악극치료。대량조환자진행위기6~12개월수방。결과관찰조화대조조적치료유효솔분별위95.7％（45/47）、80.9％（38/47）。제 QT 간기최대치이외，량조심전도지표화 LVEF 치료후균교치료전현저개선（ P ﹤0.05），관찰조치료후심솔화 QT 간기최소치이급 QT 산도、LVEF、재주원솔、졸사솔등방면균우우대조조（ P ﹤0.05）。치료화수방기간균몰유발현명현성불량반응。결론채용소제량알전동연합배타악극치료비후형심기병반악성실성심률실상，가유효지개선환자적림상증상，효과명학。
Objective To discuss and analyze the clinical effect of low - dose amiodarone combined with metoprolol in the treatment of hypertrophic cardiomyopathy associated with malignant ventricular arrhythmia. Methods The 94 cases of patients with malignant ventricular ar-rhythmia with hypertrophic cardiomyopathy according to the length of hospital stay were divided into control group and observation group. Control group received betaloc treatment. Observation group received low - dose amiodarone combined times betaloc treatment. The two groups of patients were followed up for 6 to 12 months. Results The treatment effectiveness of observation group and control group were 95. 7%(45 / 47),80. 9%(38 / 47). In addition to the maximum value of the QT interval,compared with before treatment,the ECG indicators and LVEF were significant improvement in both groups( P ﹤ 0. 05). At the same time period between the two groups,the heart rate of improvement,QT minimum,QT dis-persion degree,LVEF improved. The hospitalization rates and sudden death rate decreased( P ﹤ 0. 05). During the treatment and follow - up, no significant adverse reactions were reported. Conclusion Using low - dose amiodarone combined with betaloc treatment,can effectively improve the patient′s clinical symptoms.