CAJ | 학술논문

目的：利用 CD146标记乳腺癌中微血管密度（MVD）并分析微血管生成情况与乳腺癌临床病理特征的关系。方法收集79例乳腺癌组织标本，利用免疫组化的方法检测乳腺癌中 CD146标记的微血管密度及雌激素受体（ER）、孕激素受体（PR）的表达，分析微血管生成与乳腺癌临床病理特征的相关性。结果 CD146在乳腺癌细胞及血管内细胞中表达，高 MVD 与乳腺癌的大小和淋巴结转移呈正有关，但与乳腺癌患者的年龄、组织学分级、ER、PR 的表达情况无关。结论 CD146可作为 MVD 的一个评估标记物，并可作为评估肿瘤生长和转移的预测指标。
목적：이용 CD146표기유선암중미혈관밀도（MVD）병분석미혈관생성정황여유선암림상병리특정적관계。방법수집79례유선암조직표본，이용면역조화적방법검측유선암중 CD146표기적미혈관밀도급자격소수체（ER）、잉격소수체（PR）적표체，분석미혈관생성여유선암림상병리특정적상관성。결과 CD146재유선암세포급혈관내세포중표체，고 MVD 여유선암적대소화림파결전이정정유관，단여유선암환자적년령、조직학분급、ER、PR 적표체정황무관。결론 CD146가작위 MVD 적일개평고표기물，병가작위평고종류생장화전이적예측지표。
Objective To detect microvessel density(MVD)identified by CD146 in breast cancer and analyze the relationship between its expression and breast cancer clinicopathological features. Methods Samples of 79 breast cancer tissues from different patients were collected. Immunohistochemistry was performed to detect the expression of MVD identified by CD146,and the expression of ER,PR in breast cancer cells. The relationship between MVD and the clinicopathological features of breast cancers were analyzed. Results CD146 expressed in breast cancer and vascular endothelial cells. High MVD was positively with tumor size and lymph node metastasis. However,no correlation was found between MVD and patient year,ER and PR status in breast cancer cells. Conclusion CD146 was expressed in breast cancer and vascular endothelial cells. CD146 may plays a critical role in the process of angiogenesis. CD146 may be useful as a new evaluation factor for growth and metastasis in breast cancers.