CAJ | 학술논문

目的：观察猪骨磷蛋白对修复性牙本质形成的作用。方法用猪骨磷蛋白作盖髓剂，对小型猪健康牙行盖髓术实验，对照采用氢氧化钙盖髓，盖髓2、4、12周后，通过组织病理学观察牙本质桥形成情况。结果猪骨磷蛋白盖髓2周有团块状的修复性牙本质形成，团块周围有整齐排列的方形或矮柱状的类成牙本质细胞；4周可见大量修复性牙本质团块，呈桥形分布，修复性牙本质周围有整齐排列的柱状的类成牙本质细胞，穿髓孔未完全封闭；12周有完整的修复性牙本质桥形成，将穿髓孔封闭，牙本质结构致密，部分为管状牙本质，牙本质桥下方可见排列整齐的的成牙本质细胞。氢氧化钙盖髓2周穿髓孔下方可见薄层坏死组织；4周有修复性牙本质形成，较猪骨磷蛋白盖髓形成的修复性牙本质薄；12周有完整的修复性牙本质桥形成，牙本质结构致密，部分为管状牙本质，其厚度略低于猪骨磷蛋白盖髓。结论猪骨磷蛋白有良好的生物相容性，用其盖髓，能诱导修复性牙本质形成。
목적：관찰저골린단백대수복성아본질형성적작용。방법용저골린단백작개수제，대소형저건강아행개수술실험，대조채용경양화개개수，개수2、4、12주후，통과조직병이학관찰아본질교형성정황。결과저골린단백개수2주유단괴상적수복성아본질형성，단괴주위유정제배렬적방형혹왜주상적류성아본질세포；4주가견대량수복성아본질단괴，정교형분포，수복성아본질주위유정제배렬적주상적류성아본질세포，천수공미완전봉폐；12주유완정적수복성아본질교형성，장천수공봉폐，아본질결구치밀，부분위관상아본질，아본질교하방가견배렬정제적적성아본질세포。경양화개개수2주천수공하방가견박층배사조직；4주유수복성아본질형성，교저골린단백개수형성적수복성아본질박；12주유완정적수복성아본질교형성，아본질결구치밀，부분위관상아본질，기후도략저우저골린단백개수。결론저골린단백유량호적생물상용성，용기개수，능유도수복성아본질형성。
Objective To investigate the effect of the phosphoproteins of pig bone on dentin mineralization in vivo. Methods The phosphoprotein of pig bone was used as pulp capping in the teeth of minipigs and the calcium hydroxide served as control. The minipigs were sacrificed at 14, 30 and 90 days respectively after operation. The teeth were sampled, sliced and stained by HE for histopathological examination. Results The histopathological results revealed that the pulp cells developed into odontoblastoid cells around the major restorative dentin body after two weeks. There was thick restorative dentin body a month later. The bridge was thick and dense and mainly tubular dentin in 3 months. In the calcium hydroxide capping group, inflammatory cytonecrosis zone was found in the surface of dental pulp and only a little calcial bodies formed in two weeks. Complete restorative dentin bridge was formed in 3 mouths. Conclusion The phosphoproteins of Pig Bone can induce pulp cells to develop into odontoblasts and formation of dentin bridge with little stimulation to the dental pulp.