CAJ | 학술논문

目的验证EORTC QLQ-C15-PAL量表中文版本的有效性,进一步确定这一工具能否用于衡量中国大陆地区接受姑息治疗的晚期癌症患者的生活质量.方法以2013年5～8月在天津肿瘤医院接受姑息性治疗的187例晚期癌症患者为对象,让其参与完成量表EORTC QLQ-C30的问卷调查,从中提取EORTC QLQ-C15-PAL量表进行分析,并且让主治医师对患者进行ECOG PS评分及精神状态评定.结果共187例患者完成了问卷,各个问题的缺失率为0％～2.7％,显示患者依从度很高.除情绪功能外,其余各维度信度均较好(Cronbachα＞0.7);按照ECOGPS评分将患者分为2组,结果显示2组间评分比较差异有统计学意义;按照精神状态评定将患者分为3组,结果显示3组间评分比较差异有统计学意义;这表明EORTC QLQ-C15-PAL量表能够很好地区分上述分组.本次调查的癌症患者总体生活质量除了与疲乏维度成中度相关外(r=-0.406),与其他维度均为弱相关.决定系数R2为0.838-0.906,表明QLQ-C1S-PAL能够解释83.8％到90.6％的QLQ-C30.结论 EORTC QLQ-C15-PAL量表中文版有较高的信度和效度,适合在中国进行临床推广以测定晚期癌症患者生命质量.
목적 험증EORTC QLQ-C15-PAL량표중문판본적유효성,진일보학정저일공구능부용우형량중국대륙지구접수고식치료적만기암증환자적생활질량.방법 이2013년5～8월재천진종류의원접수고식성치료적187례만기암증환자위대상,양기삼여완성량표EORTC QLQ-C30적문권조사,종중제취EORTC QLQ-C15-PAL량표진행분석,병차양주치의사대환자진행ECOG PS평분급정신상태평정.결과 공187례환자완성료문권,각개문제적결실솔위0％～2.7％,현시환자의종도흔고.제정서공능외,기여각유도신도균교호(Cronbachα＞0.7);안조ECOGPS평분장환자분위2조,결과현시2조간평분비교차이유통계학의의;안조정신상태평정장환자분위3조,결과현시3조간평분비교차이유통계학의의;저표명EORTC QLQ-C15-PAL량표능구흔호지구분상술분조.본차조사적암증환자총체생활질량제료여피핍유도성중도상관외(r=-0.406),여기타유도균위약상관.결정계수R2위0.838-0.906,표명QLQ-C1S-PAL능구해석83.8％도90.6％적QLQ-C30.결론 EORTC QLQ-C15-PAL량표중문판유교고적신도화효도,괄합재중국진행림상추엄이측정만기암증환자생명질량.
Objective This study evaluated the validity and reliability of the standard Chinese version of the EORTC QLQ-C15-PAL (The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 palliative) to determine if this tool can be used to evaluate Chinese patients with cancer who receive palliative care.Methods In May to August 2013,187 patients with advanced cancer who received palliative treatment in Tianjin Cancer Hospital completed the questionnaires of EORTC QLQ-C30.We extracted QLQ-C15-PAL data for analysis.The doctor-in-charge assessed the ECOG PS score and the mental state of these patients.Results A total of 187 patients completed the study.The compliance rate was high,with the missing rate for each item ranging from 0 to 2.7％.Three of four multi-item-scale correlations showed Cronbach α values of ＞0.7.We divided the ECOG perform status into two groups and compared QLQ-C15-PAL subscale scores between these groups.Results showed that the questionnaire discriminated among patient subgroups with different ECOG perform status.Global quality of life was moderately correlated with the fatigue(r=-0.406) but only weakly correlated with other subscales.The proportion of variance (R2) ranged from 0.838 to 0.906,which showed that QLQ-C15-PAL subscale scores could explain between 83.8％ and 90.6％ of the original QLQ-C30.Conclusions The Chinese version of the EORTC QLQ-C15-PAL questionnaire has higher reliability and validity,which is suitable for clinic promotion in China to determine HRQL in Chinese patients with terminal cancer.