CAJ | 학술논문

目的探讨老年男性冠心病与内生性血浆睾酮及其它相关因素的关系.方法选择ACS男性患者28例、稳定型心绞痛(SAP)男性患者28例、男性健康体检者28例为对照组.分别对三组人员进行颈动脉多普勒检查,并检查外周血睾酮(T)浓度及血脂(TC、LDL-C)、血糖(Glu)、CRP等相关指标,计算BMI.结果 ACS组、SAP组外周血T、TC、LDL-C、Glu等均显著高于对照组(P＜0.05),冠心病患者(包括ACS、SAP)较对照组颈动脉中内膜厚度(IMT)、斑块个数等差异有统计学意义(P＜0.05).ACS组与SAP组比较:外周血T、Tc、LDL-C、CRP的浓度及BMI、IMT、不稳定斑块差异均有统计学意义(P＜0.05).ACS组与SAP组比较外周血Glu及硬斑例数差异无统计学意义(P＞0.05).结论老年男性冠心病患者T浓度与动脉粥样硬化、不稳定斑块、Tc、LDL-C、BMI呈负相关.
목적 탐토노년남성관심병여내생성혈장고동급기타상관인소적관계.방법 선택ACS남성환자28례、은정형심교통(SAP)남성환자28례、남성건강체검자28례위대조조.분별대삼조인원진행경동맥다보륵검사,병검사외주혈고동(T)농도급혈지(TC、LDL-C)、혈당(Glu)、CRP등상관지표,계산BMI.결과 ACS조、SAP조외주혈T、TC、LDL-C、Glu등균현저고우대조조(P＜0.05),관심병환자(포괄ACS、SAP)교대조조경동맥중내막후도(IMT)、반괴개수등차이유통계학의의(P＜0.05).ACS조여SAP조비교:외주혈T、Tc、LDL-C、CRP적농도급BMI、IMT、불은정반괴차이균유통계학의의(P＜0.05).ACS조여SAP조비교외주혈Glu급경반례수차이무통계학의의(P＞0.05).결론 노년남성관심병환자T농도여동맥죽양경화、불은정반괴、Tc、LDL-C、BMI정부상관.
Objective To investigate the relationship between elderly male patients with coronary heart diseases (CHD) and endogenous androgen level and other related factors.Methods 28 male patients with acute coronary syndrome (ACS) were chosen as research group,28 male patients with stable angina pectoris (SAP) were chosen as observation group,and 28 healthy male people were selected as control group.All of three groups were checked by carotid artery Doppler ultrasonography and the peripheral blood concentration of testosterone (T),TC,LDL-C,Glu,CRP were measured,BMI was calculated in all three groups.Results Peripheral blood concentration of T,TC,LDL-C,Glu in ACS group and SAP group were significantly higher than those of the control group(P ＜0.05).IMT and number,quality of plaque in patients with ACS and SAP were significantly different compared with the control group (P ＜ 0.05).T,Tc,LDL-C,CRP,BMI,IMT,unstable plaque were significantly different between ACS group and SAP group(P ＜ 0.05).Glu had no statistical difference between ACS group and SAP group (P ＞ 0.05).Conclusion Peripheral blood concentration of T was negatively correlated with arterosclerosis,unstable plaque,Tc,LDL-C,BMI in old male CHD patients