中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
11期
1585-1591
,共7页
肺炎支原体肺炎%中西医结合治疗%阿奇霉素%红霉素%荟萃分析
肺炎支原體肺炎%中西醫結閤治療%阿奇黴素%紅黴素%薈萃分析
폐염지원체폐염%중서의결합치료%아기매소%홍매소%회췌분석
Mycoplasma pneumonia%Chinese and Western Medicine%Azithromycin%Erythromycin%Meta analysis
目的 评价中西医结合治疗小儿肺炎支原体肺炎的临床效果.方法 收集国内关于中西医结合治疗和单纯西医治疗小儿肺炎支原体肺炎的随机对照研究文献,对结果进行Meta分析.其中,试验组进行中西医结合治疗,在应用抗生素的基础上服用各式中药煎剂;对照组进行抗生素治疗.疗效及差异评价指标以比值比(OR)、加权均数差(WMD)和95％置信区间(CI)表示.统计学分析采用Revman 2.8软件.结果 共收集国内20个随机对照研究,Meta分析结果显示:2组病例治疗后均得到明显改善,试验组痊愈率和显效率明显优于对照组,差异有统计学意义(OR=2.92,95％ CI:2.29 ～3.74,P＜0.01);试验组无效率低于对照组,差异有统计学意义(OR =0.20,95％CI:0.12 ～0.34,P＜0.01);比较2组病例的啰音消失时间、咳嗽消失时间、退热时间,试验组能在相对较短时间内使各指标恢复正常,差异有统计学意义,3者Meta分析值分别为:(WMD=-2.22,95％CI:-2.43～-2.01,P＜0.01)、(WMD=-1.61,95％ CI:-2.35～-0.86,P＜0.01)、(WMD=-0.90,95％ CI:-1.43 ～-0.37,P＜0.01);试验组不良反应发生率低于对照组,差异有统计学意义(OR =0.16,95％ CI:0.05 ～0.48,P=0.01).结论 中西医结合治疗小儿肺炎支原体肺炎疗效优于单纯西医治疗.
目的 評價中西醫結閤治療小兒肺炎支原體肺炎的臨床效果.方法 收集國內關于中西醫結閤治療和單純西醫治療小兒肺炎支原體肺炎的隨機對照研究文獻,對結果進行Meta分析.其中,試驗組進行中西醫結閤治療,在應用抗生素的基礎上服用各式中藥煎劑;對照組進行抗生素治療.療效及差異評價指標以比值比(OR)、加權均數差(WMD)和95％置信區間(CI)錶示.統計學分析採用Revman 2.8軟件.結果 共收集國內20箇隨機對照研究,Meta分析結果顯示:2組病例治療後均得到明顯改善,試驗組痊愈率和顯效率明顯優于對照組,差異有統計學意義(OR=2.92,95％ CI:2.29 ～3.74,P＜0.01);試驗組無效率低于對照組,差異有統計學意義(OR =0.20,95％CI:0.12 ～0.34,P＜0.01);比較2組病例的啰音消失時間、咳嗽消失時間、退熱時間,試驗組能在相對較短時間內使各指標恢複正常,差異有統計學意義,3者Meta分析值分彆為:(WMD=-2.22,95％CI:-2.43～-2.01,P＜0.01)、(WMD=-1.61,95％ CI:-2.35～-0.86,P＜0.01)、(WMD=-0.90,95％ CI:-1.43 ～-0.37,P＜0.01);試驗組不良反應髮生率低于對照組,差異有統計學意義(OR =0.16,95％ CI:0.05 ～0.48,P=0.01).結論 中西醫結閤治療小兒肺炎支原體肺炎療效優于單純西醫治療.
목적 평개중서의결합치료소인폐염지원체폐염적림상효과.방법 수집국내관우중서의결합치료화단순서의치료소인폐염지원체폐염적수궤대조연구문헌,대결과진행Meta분석.기중,시험조진행중서의결합치료,재응용항생소적기출상복용각식중약전제;대조조진행항생소치료.료효급차이평개지표이비치비(OR)、가권균수차(WMD)화95％치신구간(CI)표시.통계학분석채용Revman 2.8연건.결과 공수집국내20개수궤대조연구,Meta분석결과현시:2조병례치료후균득도명현개선,시험조전유솔화현효솔명현우우대조조,차이유통계학의의(OR=2.92,95％ CI:2.29 ～3.74,P＜0.01);시험조무효솔저우대조조,차이유통계학의의(OR =0.20,95％CI:0.12 ～0.34,P＜0.01);비교2조병례적라음소실시간、해수소실시간、퇴열시간,시험조능재상대교단시간내사각지표회복정상,차이유통계학의의,3자Meta분석치분별위:(WMD=-2.22,95％CI:-2.43～-2.01,P＜0.01)、(WMD=-1.61,95％ CI:-2.35～-0.86,P＜0.01)、(WMD=-0.90,95％ CI:-1.43 ～-0.37,P＜0.01);시험조불량반응발생솔저우대조조,차이유통계학의의(OR =0.16,95％ CI:0.05 ～0.48,P=0.01).결론 중서의결합치료소인폐염지원체폐염료효우우단순서의치료.
Objective To discuss the clinical efficacy of Chinese and Western medicine inmycoplasma pneumonia in children.Methods Randomized controlled trials (RCTs) on western medicine versus traditional Chinese combined with Western medicine treating children mycoplasma pneumonia were identified according to the inclusion and exclusion criteria.Methodological quality of included studies was accessed.Meta-analysis was then performed using RevMan 4.2 software.Pooled odds ratio (OR),weighted mean difference (WMD) and 95％ confidence interval (CI) were calculated.20 randomized controlled domestic researches were gathered.Results Cure rate and effective rate in the experimental group were better than those in the control group(OR =2.92,95％ CI:2.29 to 3.74,P ＜0.01).Inefficiency in the experimental group was lower than in control group; the difference was statistically significant (OR =0.20,95％ CI:0.12 to 0.34,P ＜ 0.01) ; rale disappearance time,cough disappearance time and cooling time in the experimental group were shorter than those in control group(WMD =-2.22,95％ CI:-2.43 to-2.01,P＜0.01),(WMD =-1.61,95％ CI:-2.35 to-0.86,P＜0.01),(OR=-0.90,95％ CI:-1.43 to-0.37,P =0.0008).The incidence of adverse reactions in the experimental group was lower than that in the control group; the difference was statistically significant,(WMD =0.16,95％ CI:0.05 to 0.48,P =0.001).Conclusion Treatment of mycoplasma pneumonia in children with Chinese and Western Medicine can significantly increase the efficiency of recovery; the non-efficiency and the incidence of adverse reactions can be significantly reduced.
