中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
34期
43-44
,共2页
半乳糖凝集素3%心力衰竭%炎症因子%诊断价值
半乳糖凝集素3%心力衰竭%炎癥因子%診斷價值
반유당응집소3%심력쇠갈%염증인자%진단개치
Galectin 3%Heart failure%Inflammatory factors%Diagnostic value
目的 探讨半乳糖凝集素-3(Gal-3)在心力衰竭诊断及预后判断中的价值.方法 选择68例心力衰竭患者(心力衰竭组)和68例健康体检者(对照组),比较两组及不同心功能分级心力衰竭患者Gal-3水平和随访6个月后的心血管事件发生率.结果 心力衰竭组Gal-3水平为(44.57±10.42)ng/L,对照组为(33.76±8.18)ng/L,两组比较差异有统计学意义(P＜0.01).心功能分级Ⅳ级(15例)的心力衰竭患者Gal-3水平及随访6个月后的心血管事件发生率显著高于心功能分级Ⅱ级(32例)和Ⅲ级(21例)患者[(46.45±12.21) ng/L比(38.47±9.38)、(42.31±10.23) ng/L,8/15比9.4％(3/32)、28.6％(6/21)],差异有统计学意义(P＜0.01).结论 Gal-3可作为心力衰竭患者诊断及预后判断的标志物之一,且其水平与心功能分级有相关性.
目的 探討半乳糖凝集素-3(Gal-3)在心力衰竭診斷及預後判斷中的價值.方法 選擇68例心力衰竭患者(心力衰竭組)和68例健康體檢者(對照組),比較兩組及不同心功能分級心力衰竭患者Gal-3水平和隨訪6箇月後的心血管事件髮生率.結果 心力衰竭組Gal-3水平為(44.57±10.42)ng/L,對照組為(33.76±8.18)ng/L,兩組比較差異有統計學意義(P＜0.01).心功能分級Ⅳ級(15例)的心力衰竭患者Gal-3水平及隨訪6箇月後的心血管事件髮生率顯著高于心功能分級Ⅱ級(32例)和Ⅲ級(21例)患者[(46.45±12.21) ng/L比(38.47±9.38)、(42.31±10.23) ng/L,8/15比9.4％(3/32)、28.6％(6/21)],差異有統計學意義(P＜0.01).結論 Gal-3可作為心力衰竭患者診斷及預後判斷的標誌物之一,且其水平與心功能分級有相關性.
목적 탐토반유당응집소-3(Gal-3)재심력쇠갈진단급예후판단중적개치.방법 선택68례심력쇠갈환자(심력쇠갈조)화68례건강체검자(대조조),비교량조급불동심공능분급심력쇠갈환자Gal-3수평화수방6개월후적심혈관사건발생솔.결과 심력쇠갈조Gal-3수평위(44.57±10.42)ng/L,대조조위(33.76±8.18)ng/L,량조비교차이유통계학의의(P＜0.01).심공능분급Ⅳ급(15례)적심력쇠갈환자Gal-3수평급수방6개월후적심혈관사건발생솔현저고우심공능분급Ⅱ급(32례)화Ⅲ급(21례)환자[(46.45±12.21) ng/L비(38.47±9.38)、(42.31±10.23) ng/L,8/15비9.4％(3/32)、28.6％(6/21)],차이유통계학의의(P＜0.01).결론 Gal-3가작위심력쇠갈환자진단급예후판단적표지물지일,차기수평여심공능분급유상관성.
Objective To evaluate the value of galectin-3 (Gal-3) in the diagnosis and prognosis of heart failure.Methods Sixty-eight patients with heart failure (heart failure group) and 68 healthy person (control group) were selected.The level of Gal-3 and the incidence of cardiovascular event after 6 months follow-up was compared between two groups and among different cardiac functional grading.Results The level of Gal-3 was (44.57 ± 10.42) ng/L in heart failure group,(33.76 ± 8.18) ng/L in control group,and there was significant difference between two groups (P ＜ 0.01).The level of Gal-3 and the incidence of cardiovascular event after 6 months follow-up in cardiac functional grading Ⅳ (15 cases) was higher than that in cardiac functional grading H (32 cases),Ⅲ (21 cases)[(46.45 ± 12.21) ng/L vs.(38.47 ±9.38),(42.31 ± 10.23) ng/L,8/15 vs.9.4％(3/32),28.6％(6/21)],and there was significant difference (P ＜0.01).Conclusion As the marker of heart failure,the Gal-3 has significantly clinical value on diagnosis and prognosis to segment heart failure.
