CAJ | 학술논문

为考察牛尾菜乙醇提取物抗类风湿性关节炎的作用，采用佐剂性关节炎模型研究其抗炎作用，采用醋酸扭体和福尔马林模型研究其镇痛作用。结果表明，牛尾菜乙醇提取物0.6g/kg剂量组、0.3g/kg剂量组可显著抑制大鼠佐剂性关节炎的继发性炎症，且可明显降低血清中白细胞介素-6、白细胞介素-1β和肿瘤坏死因子-α含量；0.8g/kg剂量组和0.4g/kg剂量组显著抑制醋酸扭体模型小鼠的疼痛反应；不同剂量组均可显著抑制福尔马林模型大鼠疼痛反应的2个时相。
위고찰우미채을순제취물항류풍습성관절염적작용，채용좌제성관절염모형연구기항염작용，채용작산뉴체화복이마림모형연구기진통작용。결과표명，우미채을순제취물0.6g/kg제량조、0.3g/kg제량조가현저억제대서좌제성관절염적계발성염증，차가명현강저혈청중백세포개소-6、백세포개소-1β화종류배사인자-α함량；0.8g/kg제량조화0.4g/kg제량조현저억제작산뉴체모형소서적동통반응；불동제량조균가현저억제복이마림모형대서동통반응적2개시상。
To study the anti-rheumatoid arthritis activities of ethanol extract from Smilax .riparia .A .DC .Adjuvant arthritis model in rats was used to study the anti-inflammatory activities ,and acetic acid writhing model and formalin model in mice were used to study the analgesic ef-fect .The results showed that 0.6g/kg and 0.3g/kg groups of ethanol extracts from S .riparia had an obvious inhibitory activity to adjuvant -in-duced arthritis in rats ,and decreased the level of IL -6 ,IL-1βand TNF-αin the serum ;0.8g/kg and 0.4g/kg groups had an obvious in-hibitory activity to acetic acid-induced writhing reaction in mice ;All groups had an obvious inhibitory activity to the two phases of formalin -induced pain reaction in rats .