CAJ | 학술논문

目的：研究麻仁润肠丸泻下作用的效果及其机制，并和大黄、大黄素做比较，为麻仁润肠丸的临床应用提供理论依据。方法96只SD大鼠随机分为正常对照组、麻仁润肠丸组、大黄组和大黄素组，用于检测大鼠一般状况、肠道传输功能；另96只大鼠随机分为正常对照组、麻仁润肠丸组、大黄组和大黄素组，检测肠壁组织、大肠运动频率与幅度、肠壁肠肌丛内神经的变化情况。数据均以平均数±标准误表示，每个实验至少重复三次。组间单变量统计分析采用one-way ANOVA法；组间两个单独变量统计分析采用Tukey post hoc检测以及two-way ANOVA法，以P＜0．05为差异有统计学意义。结果麻仁润肠丸长期给药对大鼠的泻下效果可稳定保持、对肠道运动功能的影响较稳定、对肠壁损伤较小、对神经系统的影响亦较小。大黄和大黄素对大鼠的一般状态影响较大，对大肠黏膜、肠道运动功能和神经系统的影响亦较大。主要表现为皮毛的清洁度较差，活动量减少，虚弱无力，精神不佳；泻下效果和对肠道运动功能影响的变化较大，晚期效果弱于麻仁润肠丸；晚期肠壁组织的损伤较为严重；早期胆碱能神经的数目增多，晚期减少；氮能神经的数目早期减少，晚期增多。结论麻仁润肠丸泻下作用温和、长期应用治疗效果优于大黄、大黄素，而其副作用却低于大黄、大黄素，长期应用不会出现严重的毒副反应，适合便秘的老年患者长期应用。
목적：연구마인윤장환사하작용적효과급기궤제，병화대황、대황소주비교，위마인윤장환적림상응용제공이론의거。방법96지SD대서수궤분위정상대조조、마인윤장환조、대황조화대황소조，용우검측대서일반상황、장도전수공능；령96지대서수궤분위정상대조조、마인윤장환조、대황조화대황소조，검측장벽조직、대장운동빈솔여폭도、장벽장기총내신경적변화정황。수거균이평균수±표준오표시，매개실험지소중복삼차。조간단변량통계분석채용one-way ANOVA법；조간량개단독변량통계분석채용Tukey post hoc검측이급two-way ANOVA법，이P＜0．05위차이유통계학의의。결과마인윤장환장기급약대대서적사하효과가은정보지、대장도운동공능적영향교은정、대장벽손상교소、대신경계통적영향역교소。대황화대황소대대서적일반상태영향교대，대대장점막、장도운동공능화신경계통적영향역교대。주요표현위피모적청길도교차，활동량감소，허약무력，정신불가；사하효과화대장도운동공능영향적변화교대，만기효과약우마인윤장환；만기장벽조직적손상교위엄중；조기담감능신경적수목증다，만기감소；담능신경적수목조기감소，만기증다。결론마인윤장환사하작용온화、장기응용치료효과우우대황、대황소，이기부작용각저우대황、대황소，장기응용불회출현엄중적독부반응，괄합편비적노년환자장기응용。
Objective The aim of the present study was to investigate the purgative effect of Maren Runchang Wan and to identify the mechanism involved compared with rhubarb ,emodin.Providing theoretical basis for the clinical application of Maren Runchang Wan.Methods 96 SD rats were randomly divided into control group,Maren Runchang Wan group,rhubarb group and emodin group .Recorded the general condition , intestinal transmission function .Another 96 rats were also randomly divided into control group , Maren Runchang Wan group,rhubarb group and emodin group .Then detected the changes of intestinal wall tissues , frequency,amplitude and myenteric plexus nerve of intestines .Results In Maren Runchang Wan group,the changes of purgative effect , intestinal movement function , intestinal wall tissue and myenteric plexus nerve were slight after long-term drug.In rhubarb group and emodin group ,the changes of general condition were apparent .the main performances changes were that the purity of the fur was poor , the movements were reduced and weak .The purgative effect and intestinal movement function were weaker than Maren Runchang Wan group in the later stage .While the injuries of intestinal wall tissues were more severe in the later stage . The amounts of cholinergic nerve were increased in the early stage and decreased in the late stage .The amounts of nitrogen nerve were decreased in the early stage and increased in the late stage.