中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
2期
330-332
,共3页
吴洁%芮广虎%宋人杰%盛蔚%龚文静
吳潔%芮廣虎%宋人傑%盛蔚%龔文靜
오길%예엄호%송인걸%성위%공문정
4-氨基-3-肼-5巯基-1 ,2 ,4-三唑%制药设备%甲醛残留
4-氨基-3-肼-5巰基-1 ,2 ,4-三唑%製藥設備%甲醛殘留
4-안기-3-정-5구기-1 ,2 ,4-삼서%제약설비%갑철잔류
AHMT%Pharmaceutical equipments%Residual formaldehyde fumigation
目的：：采用4-氨基-3-肼-5巯基-1,2,4-三唑(AHMT)法测定制药设备表面的甲醛熏蒸后残留量。方法： AHMT反应时间20 min,加入高碘酸钠振摇30 s后静置约30 s,在550 nm波长处测定吸光度。结果：甲醛溶液在0.250~2.495μg·ml-1范围内线性关系良好(r=0.9995)。玻璃板、彩钢板和不锈钢板的甲醛回收率分别为(83.42±1.48)%(n=3)、(83.63±1.94)%(n=3)和(83.94±2.28)%(n=3)。结论：该方法操作简便、结果准确,可用于制药设备表面的甲醛残留测定。
目的：：採用4-氨基-3-肼-5巰基-1,2,4-三唑(AHMT)法測定製藥設備錶麵的甲醛熏蒸後殘留量。方法： AHMT反應時間20 min,加入高碘痠鈉振搖30 s後靜置約30 s,在550 nm波長處測定吸光度。結果：甲醛溶液在0.250~2.495μg·ml-1範圍內線性關繫良好(r=0.9995)。玻璃闆、綵鋼闆和不鏽鋼闆的甲醛迴收率分彆為(83.42±1.48)%(n=3)、(83.63±1.94)%(n=3)和(83.94±2.28)%(n=3)。結論：該方法操作簡便、結果準確,可用于製藥設備錶麵的甲醛殘留測定。
목적：：채용4-안기-3-정-5구기-1,2,4-삼서(AHMT)법측정제약설비표면적갑철훈증후잔류량。방법： AHMT반응시간20 min,가입고전산납진요30 s후정치약30 s,재550 nm파장처측정흡광도。결과：갑철용액재0.250~2.495μg·ml-1범위내선성관계량호(r=0.9995)。파리판、채강판화불수강판적갑철회수솔분별위(83.42±1.48)%(n=3)、(83.63±1.94)%(n=3)화(83.94±2.28)%(n=3)。결론：해방법조작간편、결과준학,가용우제약설비표면적갑철잔류측정。
Objective:To determine the residual formaldehyde fumigation on the surface of pharmaceutical equipments by AHMT method. Methods:The reaction time of AHMT was controlled in 20 min, the solution with sodium periodate was then shaken for 30 seconds and stood for 30 seconds, and then the absorbance at 550 nm was measured. Results: The linear range of formaldehyde was 0. 250~2. 495 μg·ml-1. The recovery of formaldehyde on glass plate, color steel plate and stainless steel plate was (83. 42 ± 1. 48)%(n=3), (83. 63 ± 1. 94)%(n=3)and (83. 94 ± 2. 28)%(n=3), respectively. Conclusion:The method is proved to be convenient and accurate, and is suitable for the determination of formaldehyde on the surface of pharmaceutical equipments.
