CAJ | 학술논문

目的：：探讨常规治疗基础上加用糖皮质激素甲泼尼龙治疗重型手足口病( HFMD)的疗效。方法：重型HFMD 患儿120例随机分为激素组和非激素组各60例，非激素组给予常规治疗，激素组在此基础上加用甲泼尼龙2 mg·kg-1·d-1治疗。5d后比较两组患儿退热时间、止痉时间、住院时间及疱疹消退时间。结果：激素组患儿发热、抽搐、疱疹消退时间明显优于对照组(P<0.05)。但两组患儿住院天数差异无统计学意义(P >0.05)。结论：标准治疗基础结合糖皮质激素治疗儿童重型手足口病HFMD有较好的临床疗效。
목적：：탐토상규치료기출상가용당피질격소갑발니룡치료중형수족구병( HFMD)적료효。방법：중형HFMD 환인120례수궤분위격소조화비격소조각60례，비격소조급여상규치료，격소조재차기출상가용갑발니룡2 mg·kg-1·d-1치료。5d후비교량조환인퇴열시간、지경시간、주원시간급포진소퇴시간。결과：격소조환인발열、추휵、포진소퇴시간명현우우대조조(P<0.05)。단량조환인주원천수차이무통계학의의(P >0.05)。결론：표준치료기출결합당피질격소치료인동중형수족구병HFMD유교호적림상료효。
Objective:To explore the clinical effect of glucocorticoid methylprednisolone combined with the conventional treatment on severe hand-foot-mouth disease ( HFMD) in children. Methods:One hundred and twenty children with severe HFMD from our hos-pital were randomly divided into the hormone group and non-hormone group with 60 cases each. The non-hormone group was treated with western routine therapy, and the hormone group was treated with glucocorticoid methylprednisolone 2mg·kg-1 ·d-1 additionally. The changes in such symptoms as fever, rash, surprised and chatter, drowsiness and shock were recorded in all cases. The disappear-ance time of febrile, shock and herpes and hospital stay were compared between the two groups. Results:The clinical effect of the hor-mone group was better than the non-hormone group;it could shorten the disappearance time of febrile, shock, herpes and pharyngeal buccal redness (P<0. 05), while showed no effect on the hospital stay. Conclusion:Glucocorticoid combined with the routine thera-py in the treatment of severe HFMD in infants exhibits better clinical effect.