中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
2期
245-247
,共3页
支气管哮喘%细辛脑%白细胞介素-25%白细胞介素-27%嗜酸性粒细胞阳离子蛋白
支氣管哮喘%細辛腦%白細胞介素-25%白細胞介素-27%嗜痠性粒細胞暘離子蛋白
지기관효천%세신뇌%백세포개소-25%백세포개소-27%기산성립세포양리자단백
Asthma%Asarone%IL-25%IL-27%Eosinophils cationic protein( ECP)
目的：：观察细辛脑治疗成人哮喘患者血清白细胞介素-25(IL-25)、嗜酸性粒细胞阳离子蛋白(ECP)、白细胞介素-27(IL-27)的影响。方法：100例支气管哮喘患者随机分为观察组(55例)和对照组(45例),对照组给予常规对症治疗(吸氧、解痉平喘、抗感染等),观察组在常规治疗基础上加用细辛脑注射液24 mg加入0.9%氯化钠注射液250 ml,ivd,qd,疗程14 d。比较两组临床疗效,检测两组患者血清IL-25、ECP、IL-27治疗前后水平的变化。结果：观察组总有效率为92.7%,高于对照组(P<0.05)。细辛脑可以降低支气管哮喘患者血清IL-25、ECP、IL-27浓度的浓度,差异有统计学意义(P<0.05或0.01)。结论：细辛脑注射液可降低哮喘患者血清中IL-25、ECP、IL-27浓度,抑制炎症细胞生成,可以减轻哮喘患者的气道炎症反应。
目的：：觀察細辛腦治療成人哮喘患者血清白細胞介素-25(IL-25)、嗜痠性粒細胞暘離子蛋白(ECP)、白細胞介素-27(IL-27)的影響。方法：100例支氣管哮喘患者隨機分為觀察組(55例)和對照組(45例),對照組給予常規對癥治療(吸氧、解痙平喘、抗感染等),觀察組在常規治療基礎上加用細辛腦註射液24 mg加入0.9%氯化鈉註射液250 ml,ivd,qd,療程14 d。比較兩組臨床療效,檢測兩組患者血清IL-25、ECP、IL-27治療前後水平的變化。結果：觀察組總有效率為92.7%,高于對照組(P<0.05)。細辛腦可以降低支氣管哮喘患者血清IL-25、ECP、IL-27濃度的濃度,差異有統計學意義(P<0.05或0.01)。結論：細辛腦註射液可降低哮喘患者血清中IL-25、ECP、IL-27濃度,抑製炎癥細胞生成,可以減輕哮喘患者的氣道炎癥反應。
목적：：관찰세신뇌치료성인효천환자혈청백세포개소-25(IL-25)、기산성립세포양리자단백(ECP)、백세포개소-27(IL-27)적영향。방법：100례지기관효천환자수궤분위관찰조(55례)화대조조(45례),대조조급여상규대증치료(흡양、해경평천、항감염등),관찰조재상규치료기출상가용세신뇌주사액24 mg가입0.9%록화납주사액250 ml,ivd,qd,료정14 d。비교량조림상료효,검측량조환자혈청IL-25、ECP、IL-27치료전후수평적변화。결과：관찰조총유효솔위92.7%,고우대조조(P<0.05)。세신뇌가이강저지기관효천환자혈청IL-25、ECP、IL-27농도적농도,차이유통계학의의(P<0.05혹0.01)。결론：세신뇌주사액가강저효천환자혈청중IL-25、ECP、IL-27농도,억제염증세포생성,가이감경효천환자적기도염증반응。
Objective:To monitor the effects of asarone injections on the expression of IL-25, IL-27 and eosinophils cationic pro-tein ( ECP) in the serum of asthma patients. Methods:Totally 100 patients with bronchial asthma were randomly divided into the ob-servation group ( 55 cases ) and the control group ( 45 cases ) . The control group was treated with the conventional symptomatic treat-ment ( oxygen inhalation, spasmolysis and anti-asthma, and anti-infection, etc) . The observation group was given asarone injections 24 mg in 250 ml 0. 9% sodium chloride infusions, once a day for 14 days on the basis of the conventional therapy. The changes in symp-toms, and pulmonary function in the patients were observed with simultaneous detection of IL-25, ECP and IL-27 levels. Results:To-tal effective rate of the observation group was 92. 7%,which was higher than that of the control group (P<0. 05). Asarone injections could decrease IL-25, ECP and IL-27 levels in the observation group compared with those in the control group with statistically signifi-cant difference (P<0. 05 or 0. 01). Conclusion:Asarone injections can decrease the levels of IL-25, IL-27and ECP in the serum of asthma patients and inhibit the formation of inflammatory cells to alleviate the symptoms of airway inflammation.
