中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
2期
240-242
,共3页
泮托拉唑钠%高效毛细管电泳法%含量测定
泮託拉唑鈉%高效毛細管電泳法%含量測定
반탁랍서납%고효모세관전영법%함량측정
Pantoprazole sodium%High performance capillary electrophoresis%Determination
目的：：建立一种应用高效毛细管电泳测定注射用泮托拉唑钠中泮托拉唑钠含量的方法。方法：采用未涂层弹性石英毛细管柱,以0.01 mol·L-1的磷酸二氢钾溶液为运行缓冲液,运行电压25 kV,柱温25℃,检测波长为289 nm。结果：泮托拉唑钠在20.05~200.51μg·ml-1范围内呈良好的线性关系(r=0.9996),方法平均回收率为99.03%(RSD=0.86%,n=9)。结论：此方法简便快速,灵敏度高,重复性好,可用于注射用泮托拉唑钠的含量测定。
目的：：建立一種應用高效毛細管電泳測定註射用泮託拉唑鈉中泮託拉唑鈉含量的方法。方法：採用未塗層彈性石英毛細管柱,以0.01 mol·L-1的燐痠二氫鉀溶液為運行緩遲液,運行電壓25 kV,柱溫25℃,檢測波長為289 nm。結果：泮託拉唑鈉在20.05~200.51μg·ml-1範圍內呈良好的線性關繫(r=0.9996),方法平均迴收率為99.03%(RSD=0.86%,n=9)。結論：此方法簡便快速,靈敏度高,重複性好,可用于註射用泮託拉唑鈉的含量測定。
목적：：건립일충응용고효모세관전영측정주사용반탁랍서납중반탁랍서납함량적방법。방법：채용미도층탄성석영모세관주,이0.01 mol·L-1적린산이경갑용액위운행완충액,운행전압25 kV,주온25℃,검측파장위289 nm。결과：반탁랍서납재20.05~200.51μg·ml-1범위내정량호적선성관계(r=0.9996),방법평균회수솔위99.03%(RSD=0.86%,n=9)。결론：차방법간편쾌속,령민도고,중복성호,가용우주사용반탁랍서납적함량측정。
Objective:To establish a method for the content determination of pantoprazole sodium for injection by high performance capillary electrophoresis. Methods:The determination was performed on an uncoated elastic quartz capillary column, the running buff-er was 0. 01 mol·L-1 potassium dihydrogen phosphate buffer, the running voltage was 25kV,the column temperature was 25℃ and the detection wavelength was 289 nm. Results:The linear range was good within the concentration range of 20. 05-200. 51 μg·ml-1(r=0. 999 6). The average recovery was 99. 03%(RSD=0. 86%, n=9). Conclusion:The method is simple, sensitive and reproduci-ble, and can be used in the determination of pantoprazole sodium for injection.
