CAJ | 학술논문

目的：：建立尼莫地平脂质体中3种有机溶剂残留量的测定方法。方法：采用气相顶空色谱法,DB-624弹性毛细管柱(30 m ×0.32 nm,1.8μm),氢火焰离子化检测器(FID),氮气为载气,进样口与检测口温度均为250℃,程序升温进行测定。结果：3种残留溶剂乙醇、丙酮、乙酸乙酯均完全分离,在所考察的浓度范围内线性关系良好,平均回收率分别为98.9%,98.5%,99.4%,RSD分别为0.32%,1.12%,0.76%(n=9)。最低检测限分别为0.20,0.18,0.22μg·ml-1。结论：该顶空气相色谱法快速、准确、灵敏度高,可以用于样品中3种有机溶剂残留量的测定。
목적：：건립니막지평지질체중3충유궤용제잔류량적측정방법。방법：채용기상정공색보법,DB-624탄성모세관주(30 m ×0.32 nm,1.8μm),경화염리자화검측기(FID),담기위재기,진양구여검측구온도균위250℃,정서승온진행측정。결과：3충잔류용제을순、병동、을산을지균완전분리,재소고찰적농도범위내선성관계량호,평균회수솔분별위98.9%,98.5%,99.4%,RSD분별위0.32%,1.12%,0.76%(n=9)。최저검측한분별위0.20,0.18,0.22μg·ml-1。결론：해정공기상색보법쾌속、준학、령민도고,가이용우양품중3충유궤용제잔류량적측정。
Objective:To establish a method for determining three residual organic solvents in nimodipine liposomes. Methods:The samples were injected into a DB-624 capillary column (30 m × 0. 32 nm,1. 8 μm) by a headspace sampler and analyzed with an FID detector, the carrier gas was nitrogen, the injector temperature was 250℃, and the detector temperature was 250℃. The column temperature was programmed raised. Results:Three residual solvents, namely ethanol, acetone and acetic ether were completely sepa-rated. There was a good linearity within the experimental concentration range. The average recovery was 98. 9%,98. 5% and 99. 4%(RSD=0. 32%,1. 12%,0. 76%,n=9), respectively. The detection limits was 0. 20, 0. 18 and 0. 22μg·ml-1, respectively . Con-clusion:The method is rapid, sensitive and accurate. It can be used in the determination of residual organic solvents in nimodipine li-posomes.