CAJ | 학술논문

目的：：不同致敏原诱发豚鼠过敏性鼻炎模型的比较。方法：分别以卵蛋白( OVA)、2,4-二异氰酸甲苯酯( TDI)和互隔交链孢霉作为致敏原诱发豚鼠制备过敏性鼻炎模型,以行为学观察、血清生化水平和组织学观察,考察不同模型组与人类过敏性鼻炎的符合度。结果：OVA组与空白组比较,打喷嚏次数、抓鼻次数、血清透明质酸( HA)及IgE差异有统计学意义( P<0.001或0.01)。结论：OVA诱发过敏性鼻炎模型既在症状上符合过敏性鼻炎的典型症状,又在病理改变上与过敏性鼻炎相符合。
목적：：불동치민원유발돈서과민성비염모형적비교。방법：분별이란단백( OVA)、2,4-이이청산갑분지( TDI)화호격교련포매작위치민원유발돈서제비과민성비염모형,이행위학관찰、혈청생화수평화조직학관찰,고찰불동모형조여인류과민성비염적부합도。결과：OVA조여공백조비교,타분체차수、조비차수、혈청투명질산( HA)급IgE차이유통계학의의( P<0.001혹0.01)。결론：OVA유발과민성비염모형기재증상상부합과민성비염적전형증상,우재병리개변상여과민성비염상부합。
Objective:To compare the models of guinea pig allergic rhinitis induced by different allergens. Methods: Ovalbumin (OVA), 2,4-tolylene diisocyanate (TDI) and alternariaalternata was respectively used as the allergens to establish the model of guinea pigs allergic rhinitis. The conformity of the models and human allergic rhinitis was studied through the behavioral indices, such as the times of nose itches, nasal discharge flow, histological properties and serum HA and IgE indices. Results:The times of sneezing and scratching nose, serum HA and IgE in OVA group was significantly different from those in the control group (P<0. 001 or P<0. 01). Conclusion:The models of allergic rhinitis induced by OVA are the same as allergic rhinitis in typical symptoms and pathological changes.