CAJ | 학술논문

目的：研究Stathmin和Cathepsin B在人结直肠癌组织及其转移灶中的差异表达，探讨Stathmin和Cathepsin B在结直肠癌发生发展过程中的作用及其临床病理意义。方法用免疫组织化学染色技术检测158例高分化，中分化及低分化结直肠癌患者手术切除标本及64例相应转移灶组织中Stathmin蛋白和Cathepsin B蛋白的表达情况。结果 Stathmin蛋白及Cathepsin B蛋白在结直肠癌组织及其转移灶中均高表达；高分化结直肠癌样本中Stathmin蛋白及Cathepsin B蛋白在细胞膜或细胞浆阳性表达，而在低分化结直肠癌细胞核，细胞膜及细胞浆中可见二者的阳性表达。结论Stathmin及Cathepsin B可能是判断结直肠癌患者临床病理分级的有用指标。
목적：연구Stathmin화Cathepsin B재인결직장암조직급기전이조중적차이표체，탐토Stathmin화Cathepsin B재결직장암발생발전과정중적작용급기림상병리의의。방법용면역조직화학염색기술검측158례고분화，중분화급저분화결직장암환자수술절제표본급64례상응전이조조직중Stathmin단백화Cathepsin B단백적표체정황。결과 Stathmin단백급Cathepsin B단백재결직장암조직급기전이조중균고표체；고분화결직장암양본중Stathmin단백급Cathepsin B단백재세포막혹세포장양성표체，이재저분화결직장암세포핵，세포막급세포장중가견이자적양성표체。결론Stathmin급Cathepsin B가능시판단결직장암환자림상병리분급적유용지표。
Objective To investigate the differential expression of Stathmin and Cathepsin B in human colorectal cancer tissues and related metastatic foci .And to discuss the clinicopathological significance of these two markers .Methods Immunohistochemical staining for Stathmin and Cathepsin B was performed in the colorectal cancer tissues of 158 cases and 64 related metastatic foci .Results Both Stathmin and Cathepsin B are upregulated in colorectal cancer and related metastatic samples .The location of Stathmin and Cathepsin B transferred from cytoplasm to nuclear in low differentiation colorectal cancer samples compared with high and mediate differentiation samples .Conclusion Stathmin and Cathepsin B might be valuable biomarkers for clinical differentiation of colorectal cancer .