中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2012年
12期
1092-1094
,共3页
颜安%马慧娟%尹良爽%章旭东%汪凯
顏安%馬慧娟%尹良爽%章旭東%汪凱
안안%마혜연%윤량상%장욱동%왕개
反社会性人格障碍%决策功能%认知
反社會性人格障礙%決策功能%認知
반사회성인격장애%결책공능%인지
Antisocial personality disorder%Decision making%Cognition
目的 探讨男性反社会人格障碍(Antisocial personality disorder,ASPD)患者决策倾向.方法 将76例反社会人格障碍患者(ASPD)组与其人口学资料相匹配的无人格障碍健康对照(Healthy control,HC)组作为研究对象,通过爱荷华博弈任务(Iowa Gambling Task,IGT)进行决策功能的测试,采用焦虑自评量表(SAS)、抑郁自评量表(SDS)、简明精神状态量表(MMSE)、明尼苏达多项人格测验精神病态分量表(MMPI-Pd)和Barratt冲动量表(BIS-11)对两组被试进行背景测试.结果 ASPD组在IGT中净有利选牌数明显低于HC组[分别为(-4.13±18.27)次,(6.03±19.43)次],差异有统计学意义[t(134)=-3.132,P=0.002].对ASPD组与HC组采用2(组)×5(阶段)方差分析,比较两组不同阶段的净有利选择,发现两组间的主效应显著[F1.134)=9.811,P=0.002]；不同阶段的主效应同样显著[F(4,536)=15.456,P＜0.01].随着爱荷华博弈任务选择次数的增多,ASPD组和HC组净有利选择次数均逐渐增加,但在第三、第四、第五阶段,HC组相较ASPD组净有利选择数目显著增多[第三阶段F(1.134)=5.947,P=0.016;第四阶段F(1.134)=5.023,P=0.027;第五阶段F(1,134)=8.553,P=0.004].ASPD组净有利选择数与MMPI-Pd分数呈负相关(r=-0.232,P=0.006),而与年龄、教育程度、SAS、SDS、BIS-11评分均无相关.结论 男性反社会人格障碍患者存在决策功能障碍,其决策缺陷可能与眶额叶、背外侧前额叶以及前扣带回的结构和功能异常有关.
目的 探討男性反社會人格障礙(Antisocial personality disorder,ASPD)患者決策傾嚮.方法 將76例反社會人格障礙患者(ASPD)組與其人口學資料相匹配的無人格障礙健康對照(Healthy control,HC)組作為研究對象,通過愛荷華博弈任務(Iowa Gambling Task,IGT)進行決策功能的測試,採用焦慮自評量錶(SAS)、抑鬱自評量錶(SDS)、簡明精神狀態量錶(MMSE)、明尼囌達多項人格測驗精神病態分量錶(MMPI-Pd)和Barratt遲動量錶(BIS-11)對兩組被試進行揹景測試.結果 ASPD組在IGT中淨有利選牌數明顯低于HC組[分彆為(-4.13±18.27)次,(6.03±19.43)次],差異有統計學意義[t(134)=-3.132,P=0.002].對ASPD組與HC組採用2(組)×5(階段)方差分析,比較兩組不同階段的淨有利選擇,髮現兩組間的主效應顯著[F1.134)=9.811,P=0.002]；不同階段的主效應同樣顯著[F(4,536)=15.456,P＜0.01].隨著愛荷華博弈任務選擇次數的增多,ASPD組和HC組淨有利選擇次數均逐漸增加,但在第三、第四、第五階段,HC組相較ASPD組淨有利選擇數目顯著增多[第三階段F(1.134)=5.947,P=0.016;第四階段F(1.134)=5.023,P=0.027;第五階段F(1,134)=8.553,P=0.004].ASPD組淨有利選擇數與MMPI-Pd分數呈負相關(r=-0.232,P=0.006),而與年齡、教育程度、SAS、SDS、BIS-11評分均無相關.結論 男性反社會人格障礙患者存在決策功能障礙,其決策缺陷可能與眶額葉、揹外側前額葉以及前釦帶迴的結構和功能異常有關.
목적 탐토남성반사회인격장애(Antisocial personality disorder,ASPD)환자결책경향.방법 장76례반사회인격장애환자(ASPD)조여기인구학자료상필배적무인격장애건강대조(Healthy control,HC)조작위연구대상,통과애하화박혁임무(Iowa Gambling Task,IGT)진행결책공능적측시,채용초필자평량표(SAS)、억욱자평량표(SDS)、간명정신상태량표(MMSE)、명니소체다항인격측험정신병태분량표(MMPI-Pd)화Barratt충동량표(BIS-11)대량조피시진행배경측시.결과 ASPD조재IGT중정유리선패수명현저우HC조[분별위(-4.13±18.27)차,(6.03±19.43)차],차이유통계학의의[t(134)=-3.132,P=0.002].대ASPD조여HC조채용2(조)×5(계단)방차분석,비교량조불동계단적정유리선택,발현량조간적주효응현저[F1.134)=9.811,P=0.002]；불동계단적주효응동양현저[F(4,536)=15.456,P＜0.01].수착애하화박혁임무선택차수적증다,ASPD조화HC조정유리선택차수균축점증가,단재제삼、제사、제오계단,HC조상교ASPD조정유리선택수목현저증다[제삼계단F(1.134)=5.947,P=0.016;제사계단F(1.134)=5.023,P=0.027;제오계단F(1,134)=8.553,P=0.004].ASPD조정유리선택수여MMPI-Pd분수정부상관(r=-0.232,P=0.006),이여년령、교육정도、SAS、SDS、BIS-11평분균무상관.결론 남성반사회인격장애환자존재결책공능장애,기결책결함가능여광액협、배외측전액협이급전구대회적결구화공능이상유관.
Objective To investigate the capabilities of decision-making in male subjects with Antisocial personality disorder (ASPD).Methods A total of 76 male ASPD subjects were compared with matched 60 healthy controls on the Iowa Gambling Task.At the same time,All of them were evaluated with Self-Rating Anxiety Scale (SAS),Self-Rating Depression Scale (SDS),Mini-Mental State Examination (MMSE),the MMPI Personality Disorder Scales (MMPI-Pd) and The Barratt Impulsiveness Scale (BIS-11).Results The ASPD group selected less advantageous cards (the number of cards selected from the advantageous decks minus the number of cards selected from disadvantageous decks) than healthy controls ((-4.13 ± 18.27) time,(6.03 ± 19.43) time respectively,t (134) =-3.132,P =0.002).A 2 (group) × 5 (block) ANOVA (analysis of variance) on the cards of net advantageous from the gambling task revealed a significant main effect of group (F(1,134) =9.811,P=0.002).Meanwhile,the ANOVA revealed a significant main effect of block (F(4,5336 =15.456,P ＜ 0.001).The results showed that healthy controls and ASPD group gradually shifted their selections toward the good decks as the game progresses.The study indicated the total number of advantageous cards for subjects with antisocial personality disorder were negative correlation to the MMPI-Pd(r =-0.232,P=0.006).Conclusion The present study suggests that the decision-making impairment might be in the male subjects with antisocial personality disorder.The deficit of decision-making for ASPD might be attributed to the dysfunction of the orbitofrontal,dorsolateral frontal,and anterior cingulate cortex.
