中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2013年
1期
18-20
,共3页
颜安%陈新贵%尹良爽%张龙%章旭东%汪凯
顏安%陳新貴%尹良爽%張龍%章旭東%汪凱
안안%진신귀%윤량상%장룡%장욱동%왕개
反社会性人格障碍%风险决策%认知%执行功能
反社會性人格障礙%風險決策%認知%執行功能
반사회성인격장애%풍험결책%인지%집행공능
Antisocial personality disorder%Decision making%Cognitive%Executive function
目的 评估男性反社会人格障碍(antisocial personality disorder,ASPD)患者的风险决策功能,模拟真实情景探讨其在风险条件明确情形下的决策行为和学习反馈过程.方法 采用风险概率明确的骰子博弈测试(game of dice task,GDT)对31例ASPD患者(ASPD)组、33例健康对照(healthy controls,HC)组进行风险决策功能测试.结果 ASPD组较HC组更倾向于选择风险选项[ASPD组(10.06±5.26)分,HC组(5.42土3.29)分,t=4.201,P＜0.01].ASPD组负反馈利用率明显低于HC组,差异有统计学意义[ASPD组(0.28±0.26)分,HC组(0.68±0.32)分,t=-5.311,P＜0.01].4个选项中ASPD组选择最多的是2个数字的联合,而HC组选择最多的是3个数字的联合[选择1个数字的联合,ASPD组中位数为1(0 ～8),HC组中位数为1(0 ～2.5)(Z=-2.295,P=0.022)；3个数字:ASPD组(4.77±4.23)分；HC组(6.79±3.43)分；t=-2.100,P=0.04;4个数字:ASPD组(3.06土3.53)分；HC组(5.82±3.41)分；t=3.176,P=0.002].相关分析发现,ASPD组中选择风险选项的次数与负反馈利用率(r=-0.613,P＜0.01)、Stroop结果(r=0.566,P＜0.01)、BIS-11中运动因子(r=0.779,P＜0.01)和冲动性总分(r=0.481,P=0.006)的相关性显著.结论 ASPD患者在风险概率明确条件下存在着明显的决策倾向改变,其偏爱选择高风险选项,并与执行功能、行为冲动性和负反馈利用率相关.推测此种表现可能与前额叶皮层功能减弱有关,并可能通过执行功能和反馈处理两个过程影响决策行为.
目的 評估男性反社會人格障礙(antisocial personality disorder,ASPD)患者的風險決策功能,模擬真實情景探討其在風險條件明確情形下的決策行為和學習反饋過程.方法 採用風險概率明確的骰子博弈測試(game of dice task,GDT)對31例ASPD患者(ASPD)組、33例健康對照(healthy controls,HC)組進行風險決策功能測試.結果 ASPD組較HC組更傾嚮于選擇風險選項[ASPD組(10.06±5.26)分,HC組(5.42土3.29)分,t=4.201,P＜0.01].ASPD組負反饋利用率明顯低于HC組,差異有統計學意義[ASPD組(0.28±0.26)分,HC組(0.68±0.32)分,t=-5.311,P＜0.01].4箇選項中ASPD組選擇最多的是2箇數字的聯閤,而HC組選擇最多的是3箇數字的聯閤[選擇1箇數字的聯閤,ASPD組中位數為1(0 ～8),HC組中位數為1(0 ～2.5)(Z=-2.295,P=0.022)；3箇數字:ASPD組(4.77±4.23)分；HC組(6.79±3.43)分；t=-2.100,P=0.04;4箇數字:ASPD組(3.06土3.53)分；HC組(5.82±3.41)分；t=3.176,P=0.002].相關分析髮現,ASPD組中選擇風險選項的次數與負反饋利用率(r=-0.613,P＜0.01)、Stroop結果(r=0.566,P＜0.01)、BIS-11中運動因子(r=0.779,P＜0.01)和遲動性總分(r=0.481,P=0.006)的相關性顯著.結論 ASPD患者在風險概率明確條件下存在著明顯的決策傾嚮改變,其偏愛選擇高風險選項,併與執行功能、行為遲動性和負反饋利用率相關.推測此種錶現可能與前額葉皮層功能減弱有關,併可能通過執行功能和反饋處理兩箇過程影響決策行為.
목적 평고남성반사회인격장애(antisocial personality disorder,ASPD)환자적풍험결책공능,모의진실정경탐토기재풍험조건명학정형하적결책행위화학습반궤과정.방법 채용풍험개솔명학적투자박혁측시(game of dice task,GDT)대31례ASPD환자(ASPD)조、33례건강대조(healthy controls,HC)조진행풍험결책공능측시.결과 ASPD조교HC조경경향우선택풍험선항[ASPD조(10.06±5.26)분,HC조(5.42토3.29)분,t=4.201,P＜0.01].ASPD조부반궤이용솔명현저우HC조,차이유통계학의의[ASPD조(0.28±0.26)분,HC조(0.68±0.32)분,t=-5.311,P＜0.01].4개선항중ASPD조선택최다적시2개수자적연합,이HC조선택최다적시3개수자적연합[선택1개수자적연합,ASPD조중위수위1(0 ～8),HC조중위수위1(0 ～2.5)(Z=-2.295,P=0.022)；3개수자:ASPD조(4.77±4.23)분；HC조(6.79±3.43)분；t=-2.100,P=0.04;4개수자:ASPD조(3.06토3.53)분；HC조(5.82±3.41)분；t=3.176,P=0.002].상관분석발현,ASPD조중선택풍험선항적차수여부반궤이용솔(r=-0.613,P＜0.01)、Stroop결과(r=0.566,P＜0.01)、BIS-11중운동인자(r=0.779,P＜0.01)화충동성총분(r=0.481,P=0.006)적상관성현저.결론 ASPD환자재풍험개솔명학조건하존재착명현적결책경향개변,기편애선택고풍험선항,병여집행공능、행위충동성화부반궤이용솔상관.추측차충표현가능여전액협피층공능감약유관,병가능통과집행공능화반궤처리량개과정영향결책행위.
Objective To investigate decision making under risk in patients with antisocial personality disorder(ASPD).Methods The game of dice task (GDT) was a commonly used measure of decision making under risk.31 ASPD patients and 33 healthy controls (HC) were investigated by GDT with explicit probability.Results ASPD patients performed poorly in the entire task.ASPD selected more risky options (ASPD:10.06 ±5.26,HC:5.42 ± 3.29,t =4.201,P ＜ 0.01) compared with healthy controls.The most frequent choice made by ASPD patients was two numbers.Accordingly,the most frequent choice made by HC group was three numbers(one number:the median of ASPD patients was 1 (1-8),the median of HC was 1 (0-2.5),Z =-2.295,P =0.022) ;three numbers:ASPD:4.77 ±4.23;HC:6.79 ±3.43; t=-2.100,P=0.04;four numbers:ASPD:3.06 ±3.53;HC:5.82 ± 3.41 ; t =3.176,P=0.002).The frequency of choosing the risky options had correlation with the rate of using negative feedback(r =-0.613,P ＜ 0.01),impulsiveness (r =0.481,P =0.006) and the results of Stroop test (r =0.566,P ＜ 0.01).Conclusion Main results reveal that patients with ASPD make risky decisions significantly more often than the HC.Moreover,they show lack of capacity to advantageously utilize feedback,and correlation with executive function,impulsiveness,and negative feedback.
