中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
2期
191-193
,共3页
黄群莲%王利国%唐灿%雷燕
黃群蓮%王利國%唐燦%雷燕
황군련%왕리국%당찬%뢰연
巴中产栀子%解热效应%抗炎效应
巴中產梔子%解熱效應%抗炎效應
파중산치자%해열효응%항염효응
Gardeniae Fructus from Bazhong%Antipyretic effect%Anti-inflammatory effect
目的：：探索巴中产栀子对内毒素所致家兔发热模型的解热药理效应及其抑制0.6%冰醋酸所致小鼠腹腔毛细血管通透性增加的抗炎药理效应。方法：针对家兔耳缘静脉注射内毒素生理盐水溶液制备发热模型与0.6%冰醋酸溶液所致小鼠腹腔毛细管通透性增加的炎症模型，分别灌胃给予栀子水溶性有效部位、70%醇溶性有效部位，测定家兔体温、小白鼠腹腔液吸光度值，观察不同产地栀子的解热抗炎作用。结果：巴中产栀子提取水溶性有效部位对发热家兔的降温效果优于江西、湖北、江津产栀子(P<0.01)；巴中产栀子提取醇溶性有效部位对发热家兔的降温效果明显优于江津和江西栀子70%醇溶性有效部位(P<0.05或0.01)，与湖北产栀子比较有降低趋势，但差异无统计学意义(P>0.05)。巴中产栀子有效性部位抑制0.6%冰醋酸所致小鼠腹腔毛细血管通透性增加的效果与江西、湖北、江津产栀子相比，差异无统计学意义(P>0.05)。结论：巴中产栀子在解热方面的品质更优，疗效更佳。
目的：：探索巴中產梔子對內毒素所緻傢兔髮熱模型的解熱藥理效應及其抑製0.6%冰醋痠所緻小鼠腹腔毛細血管通透性增加的抗炎藥理效應。方法：針對傢兔耳緣靜脈註射內毒素生理鹽水溶液製備髮熱模型與0.6%冰醋痠溶液所緻小鼠腹腔毛細管通透性增加的炎癥模型，分彆灌胃給予梔子水溶性有效部位、70%醇溶性有效部位，測定傢兔體溫、小白鼠腹腔液吸光度值，觀察不同產地梔子的解熱抗炎作用。結果：巴中產梔子提取水溶性有效部位對髮熱傢兔的降溫效果優于江西、湖北、江津產梔子(P<0.01)；巴中產梔子提取醇溶性有效部位對髮熱傢兔的降溫效果明顯優于江津和江西梔子70%醇溶性有效部位(P<0.05或0.01)，與湖北產梔子比較有降低趨勢，但差異無統計學意義(P>0.05)。巴中產梔子有效性部位抑製0.6%冰醋痠所緻小鼠腹腔毛細血管通透性增加的效果與江西、湖北、江津產梔子相比，差異無統計學意義(P>0.05)。結論：巴中產梔子在解熱方麵的品質更優，療效更佳。
목적：：탐색파중산치자대내독소소치가토발열모형적해열약리효응급기억제0.6%빙작산소치소서복강모세혈관통투성증가적항염약리효응。방법：침대가토이연정맥주사내독소생리염수용액제비발열모형여0.6%빙작산용액소치소서복강모세관통투성증가적염증모형，분별관위급여치자수용성유효부위、70%순용성유효부위，측정가토체온、소백서복강액흡광도치，관찰불동산지치자적해열항염작용。결과：파중산치자제취수용성유효부위대발열가토적강온효과우우강서、호북、강진산치자(P<0.01)；파중산치자제취순용성유효부위대발열가토적강온효과명현우우강진화강서치자70%순용성유효부위(P<0.05혹0.01)，여호북산치자비교유강저추세，단차이무통계학의의(P>0.05)。파중산치자유효성부위억제0.6%빙작산소치소서복강모세혈관통투성증가적효과여강서、호북、강진산치자상비，차이무통계학의의(P>0.05)。결론：파중산치자재해열방면적품질경우，료효경가。
Objective:To explore the antipyretic effect on rabbit fever induced by endotoxin and the anti-inflammatory effect on the increase of mouse abdominal cavity capillary permeability caused by 0. 6% glacial acetic acid of Bazhong gardenia. Methods:The rab-bit fever model was made by ear margin vein injection of endotoxin in physiological saline solution, and the mouse inflammation model of abdominal cavity capillary permeability increase was established by 0. 6% glacial acetic acid solution. The animals were respectively intragastrically administrated with gardenia water-soluble effective parts and 70% alcohol-soluble effective parts. The rabbit body tem-perature and mouse celiac fluid absorbance values were detected. The effects of gardenia from different habitats were studied and com-pared. Results:The antipyretic effect of water-soluble effective parts from Bazhong gardenia extract was better than that of gardenia ex-tract from Jiangxi, Hubei and Jiangjin (P<0. 01), and that of alcohol-soluble effective parts from Bazhong gardenia extract was better than that of gardenia extract from Jiangjin and Jiangxi (P<0. 05 or 0. 01). Although compared with that of Hubei gardenia, the anti-pyretic effect of alcohol-soluble effective parts from Bazhong gardenia extract was weaker than that of gardenia extract from Hubei, the difference was not significant (P>0. 05). Bazhong gardenia could inhibit the increase of abdominal blood capillary permeability in mouse inflammation model, and the effect was better than the other gardenia, however without significant difference (P>0. 05). Con-clusion:Bazhong gardenia shows better antipyretic effect compared with that from other habitats.
