中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
27期
4418-4422
,共5页
朱圣杰%朱芳%岳宗进%王子华
硃聖傑%硃芳%嶽宗進%王子華
주골걸%주방%악종진%왕자화
实验动物%组织构建%颈椎不稳%组织工程实验造模%颈椎病%椎动脉型颈椎病%椎动脉缺血%静力性平衡%动力性平衡%动物模型%实验研究%进展%综述
實驗動物%組織構建%頸椎不穩%組織工程實驗造模%頸椎病%椎動脈型頸椎病%椎動脈缺血%靜力性平衡%動力性平衡%動物模型%實驗研究%進展%綜述
실험동물%조직구건%경추불은%조직공정실험조모%경추병%추동맥형경추병%추동맥결혈%정력성평형%동력성평형%동물모형%실험연구%진전%종술
vertebral artery%cervical spondylosis%cervical vertebrae%animal models
背景：颈椎病是颈椎椎间盘组织退行性改变及其继发病理改变累及其周围组织结构。颈椎不稳与椎-基底动脉缺血的动物模型是研究颈椎病病理生理以及治疗的关键。<br> 目的：对颈椎不稳与椎-基底动脉缺血的动物模型进行阐述，探讨动物模型实验研究的新进展。<br> 方法：由作者应用计算机检索 PubMed 数据库及 CNKI 数据库1979至2012年，在英文标题和中以“cervical instability，basal-vertebral artery ischemia”和“animal model”检索，中文文献检索以“颈椎不稳，椎动脉缺血，动物模型”为关键词，选择内容与颈椎不稳、椎动脉缺血、动物模型相关的文章，同一领域文献则选择近期发表或发表在权威杂志文章，共纳入43篇文献。<br> 结果与结论：目前建立合适的理想的颈椎病模型尚需继续探讨。利用动物颈椎病模型进行的研究，目前多集中在病因、发病机制和生物化学等方面，由于颈椎病的病因及发病机制目前尚不清楚，现有的造模方法难以全面重现人类颈椎病模型，故模型成立、阳性率及造模时间合适的、理想的颈椎病模型尚需探讨。
揹景：頸椎病是頸椎椎間盤組織退行性改變及其繼髮病理改變纍及其週圍組織結構。頸椎不穩與椎-基底動脈缺血的動物模型是研究頸椎病病理生理以及治療的關鍵。<br> 目的：對頸椎不穩與椎-基底動脈缺血的動物模型進行闡述，探討動物模型實驗研究的新進展。<br> 方法：由作者應用計算機檢索 PubMed 數據庫及 CNKI 數據庫1979至2012年，在英文標題和中以“cervical instability，basal-vertebral artery ischemia”和“animal model”檢索，中文文獻檢索以“頸椎不穩，椎動脈缺血，動物模型”為關鍵詞，選擇內容與頸椎不穩、椎動脈缺血、動物模型相關的文章，同一領域文獻則選擇近期髮錶或髮錶在權威雜誌文章，共納入43篇文獻。<br> 結果與結論：目前建立閤適的理想的頸椎病模型尚需繼續探討。利用動物頸椎病模型進行的研究，目前多集中在病因、髮病機製和生物化學等方麵，由于頸椎病的病因及髮病機製目前尚不清楚，現有的造模方法難以全麵重現人類頸椎病模型，故模型成立、暘性率及造模時間閤適的、理想的頸椎病模型尚需探討。
배경：경추병시경추추간반조직퇴행성개변급기계발병리개변루급기주위조직결구。경추불은여추-기저동맥결혈적동물모형시연구경추병병리생리이급치료적관건。<br> 목적：대경추불은여추-기저동맥결혈적동물모형진행천술，탐토동물모형실험연구적신진전。<br> 방법：유작자응용계산궤검색 PubMed 수거고급 CNKI 수거고1979지2012년，재영문표제화중이“cervical instability，basal-vertebral artery ischemia”화“animal model”검색，중문문헌검색이“경추불은，추동맥결혈，동물모형”위관건사，선택내용여경추불은、추동맥결혈、동물모형상관적문장，동일영역문헌칙선택근기발표혹발표재권위잡지문장，공납입43편문헌。<br> 결과여결론：목전건립합괄적이상적경추병모형상수계속탐토。이용동물경추병모형진행적연구，목전다집중재병인、발병궤제화생물화학등방면，유우경추병적병인급발병궤제목전상불청초，현유적조모방법난이전면중현인류경추병모형，고모형성립、양성솔급조모시간합괄적、이상적경추병모형상수탐토。
BACKGROUND:Cervical spondylosis refers to cervical intervertebral spondylotic myelopathy and secondary degenerative changes, as wel as pathological changes in surrounding tissue structures. Establishing animal model of cervical instability and vertebral-basilar artery ischemia is the key in the studies addressing cervical spondylosis pathophysiology and treatment. <br> OBJECTIVE:To establish animal model of unstable cervical spine and vertebral-basilar artery ischemia, and explore new progress of animal model imitation study. <br> METHODS:A computer-based retrieval of PubMed database and CNKI database was performed for articles published from 1979 to 2012. The key words were“cervical instability, basal-vertebral artery ischemia, animal model”in English and Chinese. The articles about cervical instability, basal-vertebral artery ischemia, and animal model were screened, and those published recently or in authorized journals were preferred in the same field. Final y 43 articles were included in this study. <br> RESULTS AND CONCLUSION:An ideal animal model of cervical disease is needed. Animal model of cervical diseases is often used for the study of disease causes, onset mechanism and biochemistry. As the causes and mechanism of cervical diseases remain unclear, the existing modeling method cannot duplicate human cervical diseases, so further studies are needed to explore the establishment of models, positive rate and modeling time.
