中国中西医结合肾病杂志
中國中西醫結閤腎病雜誌
중국중서의결합신병잡지
CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN NEPHROLOGY
2014年
6期
495-498
,共4页
陈珊珊%常明%刘书馨
陳珊珊%常明%劉書馨
진산산%상명%류서형
血液透析%脂质代谢紊乱%脑血管事件%脑出血%脑梗死
血液透析%脂質代謝紊亂%腦血管事件%腦齣血%腦梗死
혈액투석%지질대사문란%뇌혈관사건%뇌출혈%뇌경사
Hemodialysis%Lipid metabolism disorders%Cerebrovascu-lar events%Cerebral hemorrhage%Cerebral in-farction
目的：探讨维持性血液透析（ MHD）患者脂质代谢紊乱与脑血管事件发生之间的关系。方法：回顾性分析56例发生脑血管事件的MHD患者（病例组）和54例同期病情稳定的MHD患者（对照组）的临床资料。结果：发生脑血管事件的MHD患者低密度脂蛋白胆固醇（ LDL-c）水平明显高于对照组。对亚组进行单因素分析发现，与对照组相比，脑出血亚组总胆固醇（ TC）明显降低；脑梗死亚组TC、LDL-c明显升高；多因素分析发现脑梗死亚组主要表现为LDL-c升高。结论：MHD患者发生脑血管事件的脂质代谢紊乱主要表现为LDL-c升高为主；总胆固醇降低可能是MHD患者并发脑出血的重要危险因素，LDL-c升高可能是MHD患者并发脑梗死的重要危险因素。
目的：探討維持性血液透析（ MHD）患者脂質代謝紊亂與腦血管事件髮生之間的關繫。方法：迴顧性分析56例髮生腦血管事件的MHD患者（病例組）和54例同期病情穩定的MHD患者（對照組）的臨床資料。結果：髮生腦血管事件的MHD患者低密度脂蛋白膽固醇（ LDL-c）水平明顯高于對照組。對亞組進行單因素分析髮現，與對照組相比，腦齣血亞組總膽固醇（ TC）明顯降低；腦梗死亞組TC、LDL-c明顯升高；多因素分析髮現腦梗死亞組主要錶現為LDL-c升高。結論：MHD患者髮生腦血管事件的脂質代謝紊亂主要錶現為LDL-c升高為主；總膽固醇降低可能是MHD患者併髮腦齣血的重要危險因素，LDL-c升高可能是MHD患者併髮腦梗死的重要危險因素。
목적：탐토유지성혈액투석（ MHD）환자지질대사문란여뇌혈관사건발생지간적관계。방법：회고성분석56례발생뇌혈관사건적MHD환자（병례조）화54례동기병정은정적MHD환자（대조조）적림상자료。결과：발생뇌혈관사건적MHD환자저밀도지단백담고순（ LDL-c）수평명현고우대조조。대아조진행단인소분석발현，여대조조상비，뇌출혈아조총담고순（ TC）명현강저；뇌경사아조TC、LDL-c명현승고；다인소분석발현뇌경사아조주요표현위LDL-c승고。결론：MHD환자발생뇌혈관사건적지질대사문란주요표현위LDL-c승고위주；총담고순강저가능시MHD환자병발뇌출혈적중요위험인소，LDL-c승고가능시MHD환자병발뇌경사적중요위험인소。
Objective:To investigate the relationship of lipid metab-olism disorders and cerebrovascular events in mainte-nance hemodialysis patients( MHD). Nethods:We retrospectively analyzed the clinical data of 56 MHD patients with cerebrovascular events( case group)and 54 MHD patients with stable state( control group). Results:The level of LDL-c of MHD patients with cere-brovascular events are significantly higher than the controlgroup. The results of subgroup from univariate analysis showed that level of total cholesterol( TC)in Cerebral hemorrhage subgroup significantly lower;the level of TC and LDL-c in Cerebral infarcti -on group significantly rise. Multiariable analysis found that level of LDL-c in cerebral infarction subgroup is significantly rise. Conclu-sion:The lipid metabolism diso-rders of MHD patients with cerebrovascular events is mainly the level of LDL-c rise. The reduce of level of TC may be the important risk factor for MHD patients complicated by cerebral hemorrhage. The rise of level of LDL-c may be the important risk factor for MHD patients complicated bycerebral infarction.
