CAJ | 학술논문

目的：观察骨碎补总黄酮对系膜增生性肾小球肾炎大鼠血IL-6及尿蛋白的影响。方法：利用免疫法制备大鼠系膜增生性肾小球肾炎模型，将大鼠分为骨碎补总黄酮组（治疗组）、病理对照组（模型组）、正常对照组，检测各组24 h尿蛋白、血清IL-6，并观察肾脏病理改变。结果：模型组大鼠肾脏系膜细胞明显增生，与正常对照组比较24 h尿蛋白定量及血清IL-6明显升高（P＜0．05）；治疗组大鼠肾脏系膜细胞增生减轻，24 h尿蛋白、血IL-6均明显低于模型组（P＜0．05）。结论：骨碎补总黄酮能降低系膜增生性肾小球肾炎大鼠尿蛋白，降低血清IL-6水平，减轻系膜细胞增生和细胞外基质增加，延缓或减轻肾组织损伤，保护肾功能。
목적：관찰골쇄보총황동대계막증생성신소구신염대서혈IL-6급뇨단백적영향。방법：이용면역법제비대서계막증생성신소구신염모형，장대서분위골쇄보총황동조（치료조）、병리대조조（모형조）、정상대조조，검측각조24 h뇨단백、혈청IL-6，병관찰신장병리개변。결과：모형조대서신장계막세포명현증생，여정상대조조비교24 h뇨단백정량급혈청IL-6명현승고（P＜0．05）；치료조대서신장계막세포증생감경，24 h뇨단백、혈IL-6균명현저우모형조（P＜0．05）。결론：골쇄보총황동능강저계막증생성신소구신염대서뇨단백，강저혈청IL-6수평，감경계막세포증생화세포외기질증가，연완혹감경신조직손상，보호신공능。
Objective:To investigate the effect of Rhizoma Drynariae Flavones on levels of Serum IL-6 and proteinuria in mesangial proliferative glomerulonephritis rats. Nethods:Model of mesangial proliferative glomerulonephritis was made with immuni-zation. Divid Waster rats into 3 groups:Rhizoma Drynariae Flavones group( treatment groups)、pathological control group( model con-trol group)and normal control group. Each group of the level of 24 h urine protein and Serum IL-6 were determined,And to observe the renal pathological changes. Results:In the model control group,the morphological changes in renal tissue showed that mesangial cells proliferated obviously,the level of 24 h urine protein and Serum IL-6 in the model control group were obviously higher than those in the normal control(P<0. 05). In the treatment group,the morphological changes in renal tissue showed that mesangial cells proliferated lightly,the level of 24 h urine protein and Serum IL-6 in the treatment group were obviously lower than those in the mod-el control group(P<0. 05). Conclusion:Rhizoma Drynariae Flavones can reduce the level of 24 h urine protein and Serum IL-6, decrease the mesangial cells proliferation and the extracelluar matrix accumulation,and postpones or relives the renal tissue damage. So it plays a role in protecting the renal function in rats with mesangioproliferative glomerulonephritis.