CAJ | 학술논문

目的：研究在一定温度条件下(35℃),头孢噻肟钠在不同注射液中的稳定性及抗菌活性。方法：采用在实验温度(35℃)下,药物在0.9%氯化钠、5%、10%葡萄糖注射液中各时间点的百分含量(C%),并且以lgC对时间t作图,并计算其降解速率常数K以及T0.9。同时配置不同注射液的头孢噻肟钠稀释液,进行抗菌活性研究。结果：在三种注射液中,0.9%氯化钠注射液能够使头孢噻肟钠更稳定存在,降解速率常数K较小。5%葡萄糖注射液中头孢噻肟钠的抗菌活性更好。结论：头孢噻肟钠的稳定性及抗菌活性与注射液种类有关,在日常使用时要注意。
목적：연구재일정온도조건하(35℃),두포새우납재불동주사액중적은정성급항균활성。방법：채용재실험온도(35℃)하,약물재0.9%록화납、5%、10%포도당주사액중각시간점적백분함량(C%),병차이lgC대시간t작도,병계산기강해속솔상수K이급T0.9。동시배치불동주사액적두포새우납희석액,진행항균활성연구。결과：재삼충주사액중,0.9%록화납주사액능구사두포새우납경은정존재,강해속솔상수K교소。5%포도당주사액중두포새우납적항균활성경호。결론：두포새우납적은정성급항균활성여주사액충류유관,재일상사용시요주의。
To Study stability and antibacterial activity of cefotaxime sodium for injection under conditions of constant temperature (35°C).Methods:Studing the percentage content of drugs in 0.9%sodium chloride,5%,10%glucose injection at each time point under experimental temperature (35°C),and time t plot ed lgC,and calculate the degradation rate K and T0.9.and configure different injection dilutions of the cefotaxime sodium simultaneously to study the antibacterial activity.Results:In the three injections, 0.9%sodium chloride injection could make cefotaxime sodium more stable,degradation rate K is smal er,and have bet er antibacterial activity in 5%dextrose injection.Conclusion:Stability and antibacterial activity of cefotaxime sodium have relation to injection type,and we should pay at ention to in the day-to-day use.