CAJ | 학술논문

骨质疏松（osteoporosis， OP）是一种以骨量减少，骨的微细结构破坏为特征的全身代谢性骨骼疾病。瘦素（Leptin， Lep）是由脂肪细胞分泌的一种肽类激素，对骨量正面和负面都有影响，并对骨代谢发挥调节作用。在体外，Lep可调节成骨细胞的增殖，抑制成骨细胞依赖的破骨细胞的重吸收；在体内主要是负面作用，Lep抑制脑干中5-羟色胺（5-hydroxy tryptamine，5-ht）的合成，增加交感神经信号由下丘脑到骨的输出。但临床试验中关于Lep与老年性OP之间的相关性和Lep在中枢神经系统、外周组织中的作用及存在的问题尚未明确，文中就Lep与老年性OP的相关性最新研究进展作一综述。
골질소송（osteoporosis， OP）시일충이골량감소，골적미세결구파배위특정적전신대사성골격질병。수소（Leptin， Lep）시유지방세포분비적일충태류격소，대골량정면화부면도유영향，병대골대사발휘조절작용。재체외，Lep가조절성골세포적증식，억제성골세포의뢰적파골세포적중흡수；재체내주요시부면작용，Lep억제뇌간중5-간색알（5-hydroxy tryptamine，5-ht）적합성，증가교감신경신호유하구뇌도골적수출。단림상시험중관우Lep여노년성OP지간적상관성화Lep재중추신경계통、외주조직중적작용급존재적문제상미명학，문중취Lep여노년성OP적상관성최신연구진전작일종술。
Osteoporosis is a kind of systemic metabolic bone diseases ,characterized by bone loss , bone subtle structural dam-age.Leptin is a peptide hormone which secreted by fat cells , that has both positive and negative effects to the bone , and plays a role of regulating on bone metabolism .In vitro, Leptin can regulate proliferation of osteoblast and inhibit reabsorption of osteoblasts depend on osteoclast.In vivo, Leptin can inhibit the synthesis of serotonin in the brain stem and increase the sympathetic nerve signals output by the hypothalamus to the bone , it mainly has a negative effect .But clinical trials about the correlation between Leptin and senile oste-oporosis, the role of Leptin in the central nervous system and peripheral tissue problems are still unclear .In this paper, we will make a comprehensive overview about the latest research progress in the correlation between leptin and senile osteoporosis .