CAJ | 학술논문

目的探讨心肌肌酸激酶同工酶(CK-MB)在呼吸道合胞病毒(respiratory syncytial virus,RSV)感染中的动态变化规律,并分析CK-MB/CK对于心肌损害的诊断价值.方法 2010年至2013年在本院住院RSV感染伴有CK-MB/CK＞ 5％的患儿,共577例,其中男317例,女260例,年龄2～18个月,其中心肌损害共44例,比较伴有心肌损害与未伴有心肌损害RSV感染患儿的CK-MB动态变化规律,并对采用营养心肌治疗和常规治疗的患儿CK-MB进行对比分析,采用受试者操作特征曲线分析CK-MB/CK对心肌损害的预测价值.结果 RSV感染患儿约46.5％伴有CK-MB异常,少数(3.5％)伴有心肌损害,伴有心肌损害与未伴有心肌损害RSV感染患儿CK-MB达到高峰及持续异常时间不同,未伴有心肌损害患儿是否营养心肌治疗CK-MB差异无统计学意义(P＞0.05),CK-MB/CK预测心肌损害曲线下面积为0.663(95％ CI 0.578,0.747).结论 CK-MB在小儿RSV感染过程中有其固有的变化规律,对于心肌损害的诊断价值低.
목적 탐토심기기산격매동공매(CK-MB)재호흡도합포병독(respiratory syncytial virus,RSV)감염중적동태변화규률,병분석CK-MB/CK대우심기손해적진단개치.방법 2010년지2013년재본원주원RSV감염반유CK-MB/CK＞ 5％적환인,공577례,기중남317례,녀260례,년령2～18개월,기중심기손해공44례,비교반유심기손해여미반유심기손해RSV감염환인적CK-MB동태변화규률,병대채용영양심기치료화상규치료적환인CK-MB진행대비분석,채용수시자조작특정곡선분석CK-MB/CK대심기손해적예측개치.결과 RSV감염환인약46.5％반유CK-MB이상,소수(3.5％)반유심기손해,반유심기손해여미반유심기손해RSV감염환인CK-MB체도고봉급지속이상시간불동,미반유심기손해환인시부영양심기치료CK-MB차이무통계학의의(P＞0.05),CK-MB/CK예측심기손해곡선하면적위0.663(95％ CI 0.578,0.747).결론 CK-MB재소인RSV감염과정중유기고유적변화규률,대우심기손해적진단개치저.
Objective To study the dynamic variation of mbisoenzyme of creatine kinase(CK-MB) in the infected course of respiratory syncytial virus and explore the value of CK-MB/CK in the diagnosis of myocardial damage.Methods A total of 577 pediatric patients (317 males,260 females,aged 2 ～ 18 months) with CK-MB/CK ＞5％ from 2010 to 2013 were enrolled in this study (44 complicated by myocardial damage).Five hundred and thirty-three patients with high values CK-MB simply were randomly divided into treatment group (n =243) and control group(n =290).The dynamic variation of CK-MB were investigated.The diagnosis analyzed by receiver operating characteristic (ROC)curve was used to explore the predictive value of differential diagnosis between the pediatric patients with myocardial damage and without myocardial damage.Results Approximately 46.5％ of cases with rotavirus diarrhea had higher CK-MB and 3.5％ of cases had myocardial damage.The time of CK-MB achieved peak and anomalous duration was different between the cases with myocardial damage and without myocardial damage.There was no statistical significance between the cases with or without protecting myocardial(P ＞ 0.05).The ROC curves were constructed with area under the ROC curves of 0.663 (95 ％ CI 0.578,0.747).Conclusion The blood levels of CK-MB in children with respiratory syncytial virus infection existed obvious dynamic variety,which contributed little value to the diagnosis of myocardial damage.