CAJ | 학술논문

目的：探讨2型糖尿病、血脂水平与颈动脉硬化的关系。方法选取150名疗养的离退休干部为对象，其中63例患有2型糖尿病为糖尿病组，87名无糖尿病者为对照组，分别进行血糖、血脂相关指标检测，用彩色多普勒超声对颈动脉血管进行检查，并进行单因素对比分析；采用多元线性回归方法分别对两组的颈动脉硬化程度评分与检测的各项血脂指标作分析，评价两者的相关性。结果糖尿病组总胆固醇（TCH ）、三酰甘油（TG）、低密度脂蛋白（LDL）、载脂蛋白B （ApoB）水平均高于对照组（P＜0.05）。两组的颈动脉超声均显示有不同程度硬化表现，但糖尿病组的颈动脉硬化程度、斑块检出率及累及多支血管检出率均高于对照组（P＜0.05）。两组间血流峰值流速在颈总动脉和颈内动脉的差异有统计学意义（P＜0.01）。颈动脉硬化程度评分与检测的各项血脂指标间的多元线性回归分析显示，糖尿病组的复相关系数为0.870（P＜0.01），对照组为0.902（P＜0.01），两组结果均说明颈动脉硬化程度与血脂水平存在相关。结论高血脂是2型糖尿病患者血管病变的重要促进因素；颈动脉超声检查是早期发现糖尿病患者血管病变的较好检查手段。
목적：탐토2형당뇨병、혈지수평여경동맥경화적관계。방법선취150명요양적리퇴휴간부위대상，기중63례환유2형당뇨병위당뇨병조，87명무당뇨병자위대조조，분별진행혈당、혈지상관지표검측，용채색다보륵초성대경동맥혈관진행검사，병진행단인소대비분석；채용다원선성회귀방법분별대량조적경동맥경화정도평분여검측적각항혈지지표작분석，평개량자적상관성。결과당뇨병조총담고순（TCH ）、삼선감유（TG）、저밀도지단백（LDL）、재지단백B （ApoB）수평균고우대조조（P＜0.05）。량조적경동맥초성균현시유불동정도경화표현，단당뇨병조적경동맥경화정도、반괴검출솔급루급다지혈관검출솔균고우대조조（P＜0.05）。량조간혈류봉치류속재경총동맥화경내동맥적차이유통계학의의（P＜0.01）。경동맥경화정도평분여검측적각항혈지지표간적다원선성회귀분석현시，당뇨병조적복상관계수위0.870（P＜0.01），대조조위0.902（P＜0.01），량조결과균설명경동맥경화정도여혈지수평존재상관。결론고혈지시2형당뇨병환자혈관병변적중요촉진인소；경동맥초성검사시조기발현당뇨병환자혈관병변적교호검사수단。
Objective ToevaluatetherelationshipbetweentypeIIdiabetes,hyperlipidlevelandcarotidartery arthrosclerosisbyultrasonography.Methods Atotalof150retiredofficerswereselected,ofwhich63diabeticpatients were divided into case group while 87 subjects free of diabetes were divided into control group.Blood laboratory examination wasconductedandthemanifestationofcarotidarterywasexaminedbyultrasonography.Results TCH,TG,LDLand ApoB of case group were significantly higher than those in control group (P<0.05 ).The intimamedia thickness (IMT)of carotid artery in case group was increased significantly (P<0.05 ).Moreover,arteries narrowing and plaque were more than those in control group (both P <0.05 ).T peak velocity in carotid artery and internal carotid were of statistical significance between two groups (P<0.01 ).Furthermore,multiple linear regression analysis considering the degree of carotid artery arthrosclerosis and serum lipid showed that multiple correlation coefficient of case group was 0.870 (P<0.01)and0.902(P<0.01)ofcontrolgroup.Conclusion Hyperlipidemiamayhavethepromoteeffectontheformation of arteriosclerosis plaque and ultrasonography could be one of the effective methods to detect early vessel lesion of diabetic patients.