CAJ | 학술논문

目的：观察SD大鼠反复灌胃给予祖卡木颗粒的长期毒性反应。方法 SD大鼠120只,雌雄各半,按体质量随机分为对照组及低、中、高剂量组。对照组给予羧甲基纤维素钠,低、中、高剂量组分别给予祖卡木颗粒0.72,1.43,2.86 g·kg-1·d-1,po,qd,连续1个月；停药后恢复期2周。结果高剂量组3只动物仅给药期间出现1 d稀便、腹泻。给药末期,与对照组比较,高剂量组白细胞计数、红细胞计数、血红蛋白、血细胞比容及氯水平升高,低、中、高剂量组凝血酶原时间缩短；低、中、高剂量组血尿素氮、丙氨酸氨基转移酶、总胆固醇、天冬氨酸氨基转移酶降低,组织病理学检查无明显变化。结论祖卡木颗粒连续灌胃1个月,对大鼠无明显毒性,未见明显毒性反应剂量为1.4 g·kg-1·d-1(相当于生药20.8 g·kg-1·d-1)。
목적：관찰SD대서반복관위급여조잡목과립적장기독성반응。방법 SD대서120지,자웅각반,안체질량수궤분위대조조급저、중、고제량조。대조조급여최갑기섬유소납,저、중、고제량조분별급여조잡목과립0.72,1.43,2.86 g·kg-1·d-1,po,qd,련속1개월；정약후회복기2주。결과고제량조3지동물부급약기간출현1 d희편、복사。급약말기,여대조조비교,고제량조백세포계수、홍세포계수、혈홍단백、혈세포비용급록수평승고,저、중、고제량조응혈매원시간축단；저、중、고제량조혈뇨소담、병안산안기전이매、총담고순、천동안산안기전이매강저,조직병이학검사무명현변화。결론조잡목과립련속관위1개월,대대서무명현독성,미견명현독성반응제량위1.4 g·kg-1·d-1(상당우생약20.8 g·kg-1·d-1)。
Objective To study the chronic toxicology of Zukamu granules in rats. Methods A total of 120 healthy SD rats ( male  female = 1 1 ) were randomly divided into the control, low ( 0. 72 g · kg-1 · d-1 ), middle (1.43 g·kg-1·d-1),and high (2.86 g·kg-1·d-1) doses of Zukamu granules. The drug was given orally,once daily for a month,and the controls were given with sodium carboxymethyl cellulose. A 2-week recovery period was allowed after the drug withdrawal. Results Three rats in the high dose group developed diarrhea and loose stools for one day. Compared with the control group,the white blood cells ( WBC) ,red blood cells ( RBC) ,hemoglobin ( HGB) ,hematocrit ( HCT) and chlorine ( Cl-) in the high dose group increased. Prothrombin time ( PT ) , blood urea nitrogen ( BUN ) , alanine aminotransferase ( ALT ) , cholesterol(CHO),and aspartate aminotransferase (AST) decreased markededly in the low,middle and high dose group. No obvious change was found in histopathological examination. Conclusion No obvious toxicity was observed in SD rats treated with Zukamu granules at 1. 4g·kg-1·d-1(equivalently to crude drug of 20. 8 g·kg-1·d-1) given orally for one month.