CAJ | 학술논문

目的：观察复方血栓通胶囊改善脑缺血与耐缺氧的作用。方法将昆明小鼠随机分为假手术组(正常对照组),模型对照组,复方血栓通胶囊低、中、高(0.75,1.50,2.25 g·kg-1)剂量组,尼莫地平片组和脑安胶囊组,均连续灌胃给药7d。结扎单侧颈总动脉制备小鼠实验性脑缺血模型,观察其脑含水量、脑卒中指数；耐缺氧实验观察小鼠常压耐缺氧、亚硝酸钠中毒、急性脑缺氧存活时间。结果复方血栓通胶囊低、中、高剂量组均能不同程度地降低单侧颈总动脉结扎小鼠脑含水量,减小脑卒中指数(P<0.05,P<0.01)；均能不同程度地延长小鼠常压耐缺氧、亚硝酸钠中毒、急性脑缺氧存活时间(P<0.05,P<0.01)。结论复方血栓通胶囊具有改善小鼠脑缺血和耐缺氧的作用。
목적：관찰복방혈전통효낭개선뇌결혈여내결양적작용。방법장곤명소서수궤분위가수술조(정상대조조),모형대조조,복방혈전통효낭저、중、고(0.75,1.50,2.25 g·kg-1)제량조,니막지평편조화뇌안효낭조,균련속관위급약7d。결찰단측경총동맥제비소서실험성뇌결혈모형,관찰기뇌함수량、뇌졸중지수；내결양실험관찰소서상압내결양、아초산납중독、급성뇌결양존활시간。결과복방혈전통효낭저、중、고제량조균능불동정도지강저단측경총동맥결찰소서뇌함수량,감소뇌졸중지수(P<0.05,P<0.01)；균능불동정도지연장소서상압내결양、아초산납중독、급성뇌결양존활시간(P<0.05,P<0.01)。결론복방혈전통효낭구유개선소서뇌결혈화내결양적작용。
Objective To study the effects of the compound xueshuantong capsule ( FXC) against cerebral ischemia and hypoxia in mice. Methods KM mice were randomly divided into the sham operation group ( normal control group) , model control group, positive control group and FXC at high-,medium-and low-dose(0. 75,1. 50,and 2. 25 g·kg-1 ) groups. After intragastric administration for 7consecutive days,cerebral ischemia model was established by unilateral carotid arteries ligation. The cerebral water content and stroke index were recorded. The viability of the mice was determined by testing atmospheric hypoxia,sodium nitrite poisoning and acute cerebral anoxia. Results FXC decreased water content and stroke index of the mice suffered from unilateral carotid artery ligation dose-dependently (P<0. 05,P<0. 01) . It also prolonged the survival of mice by tolerating absence of oxygen,sodium nitrite poisoning and acute cerebral anoxia (P<0. 05,P<0. 01). Conclusion FXC has a protective effect on cerebral ischemia and hypoxia in mice.