疑难病杂志
疑難病雜誌
의난병잡지
JOURNAL OF DIFFICULT AND COMPLICATED CASES
2014年
7期
732-735
,共4页
方朝晖%赵进东%牛云飞%倪英群%陆瑞敏%忻凌%范青云%罗云%杨慧
方朝暉%趙進東%牛雲飛%倪英群%陸瑞敏%忻凌%範青雲%囉雲%楊慧
방조휘%조진동%우운비%예영군%륙서민%흔릉%범청운%라운%양혜
阿托伐他汀%糖尿病,2型%颈动脉粥样硬化%颈动脉内中膜厚度%系统评价
阿託伐他汀%糖尿病,2型%頸動脈粥樣硬化%頸動脈內中膜厚度%繫統評價
아탁벌타정%당뇨병,2형%경동맥죽양경화%경동맥내중막후도%계통평개
Atorvastatin%Diabetes,type 2%Carotid atherosclerosis%Carotid artery intima-media thickness%System review
目的:系统评价阿托伐他汀20 mg辅治2型糖尿病合并颈动脉粥样硬化患者的有效性和安全性。方法计算机检索中国生物医学文献数据库、中国期刊全文数据库、万方期刊数据库等及手工检索相关文献,查找有关阿托伐他汀20 mg治疗2型糖尿病合并颈动脉粥样硬化患者的随机对照试验,按照Cochrane系统评价的方法,客观评价纳入文献的质量,提取有效数据,采用RevMan 5.2软件进行Meta分析。结果共纳入6个随机对照试验,包括545例患者。结果显示,与糖尿病常规治疗或糖尿病常规治疗联合阿托伐他汀10 mg比较,糖尿病常规治疗联合阿托伐他汀20 mg能降低颈动脉内中膜厚度(IMT)(SMD =0.96,95%CI 0.50~1.43, P <0.01),不良事件发生率差异无统计学意义( OR=0.47,95%CI 0.18~1.22, P >0.05)。结论阿托伐他汀20 mg辅治2型糖尿病合并颈动脉粥样硬化患者是有效和安全的。
目的:繫統評價阿託伐他汀20 mg輔治2型糖尿病閤併頸動脈粥樣硬化患者的有效性和安全性。方法計算機檢索中國生物醫學文獻數據庫、中國期刊全文數據庫、萬方期刊數據庫等及手工檢索相關文獻,查找有關阿託伐他汀20 mg治療2型糖尿病閤併頸動脈粥樣硬化患者的隨機對照試驗,按照Cochrane繫統評價的方法,客觀評價納入文獻的質量,提取有效數據,採用RevMan 5.2軟件進行Meta分析。結果共納入6箇隨機對照試驗,包括545例患者。結果顯示,與糖尿病常規治療或糖尿病常規治療聯閤阿託伐他汀10 mg比較,糖尿病常規治療聯閤阿託伐他汀20 mg能降低頸動脈內中膜厚度(IMT)(SMD =0.96,95%CI 0.50~1.43, P <0.01),不良事件髮生率差異無統計學意義( OR=0.47,95%CI 0.18~1.22, P >0.05)。結論阿託伐他汀20 mg輔治2型糖尿病閤併頸動脈粥樣硬化患者是有效和安全的。
목적:계통평개아탁벌타정20 mg보치2형당뇨병합병경동맥죽양경화환자적유효성화안전성。방법계산궤검색중국생물의학문헌수거고、중국기간전문수거고、만방기간수거고등급수공검색상관문헌,사조유관아탁벌타정20 mg치료2형당뇨병합병경동맥죽양경화환자적수궤대조시험,안조Cochrane계통평개적방법,객관평개납입문헌적질량,제취유효수거,채용RevMan 5.2연건진행Meta분석。결과공납입6개수궤대조시험,포괄545례환자。결과현시,여당뇨병상규치료혹당뇨병상규치료연합아탁벌타정10 mg비교,당뇨병상규치료연합아탁벌타정20 mg능강저경동맥내중막후도(IMT)(SMD =0.96,95%CI 0.50~1.43, P <0.01),불량사건발생솔차이무통계학의의( OR=0.47,95%CI 0.18~1.22, P >0.05)。결론아탁벌타정20 mg보치2형당뇨병합병경동맥죽양경화환자시유효화안전적。
Objective To systematic review the effectiveness and safety of 20 mg atorvastatin treatment in type 2 dia-betes with carotid atherosclerosis .Methods Computer retrieval China biomedical literature database , China periodical full text database , Wanfang periodical database and manual search of relevant literature to find the randomized controlled trial of using 20 mg atorvastatin in treatment of type 2 diabetic patients with carotid artery atherosclerosis , according to the Cochrane system evaluation method , the objective evaluation of the quality of literature in the extraction of effective data , Meta-analysis were analyzed by RevMan 5.2 software.Results 6 randomized controlled trials , including 545 patients were enrolled .The results showed that , with the conventional treatment of diabetes or combined with atorvastatin 10 mg, the conventional treat-ment of diabetes combined with atorvastatin 20 mg can reduce the carotid artery intima-media thickness (IMT) (SMD=0.96, 95%CI 0.50-1.43, P <0.01), adverse event rates were not statistically significant (OR=0.47, 95% CI 0.18-1.22, P >0.05).Conclusion It demonstrated that atorvastatin(20 mg) in treatment of type 2 diabetes with carotid atherosclero-sis is effective and safety .