CAJ | 학술논문

目的：探讨不同时间给予氟比洛芬酯（ FA）注射液对结直肠肿瘤切除术患者术后血浆炎性因子表达的影响。方法选择择期结直肠肿瘤切除术患者40例，随机分为2组，每组20例。A组：手术开皮前30 min给予FA 100 mg；B组：手术开皮后30 min给予FA 100 mg。术后均行舒芬太尼（ SF）静脉自控镇痛（ PCIA）。比较2组术前及术后6 h、24 h血浆白介素-2（IL-2）、白介素-6（ IL-6）、白介素-10（IL-10）、肿瘤坏死因子（TNF-α）、巨噬细胞-集落刺激因子（ M-CSF）的浓度。结果与治疗前比较，2组术后6 h、24 h IL-2水平均降低，而IL-6和IL-10水平均升高（ P ＜0．01）；与B组比较，A组术后6 h、24 h时IL-2升高， IL-6降低（ P均＜0．05）；与B组比较，A组术后6 h IL-10水平升高（ P ＜0．05）。2组患者各时间点TNF-α和M-CSF水平差异均无统计学意义（ P﹥0．05）。结论手术前静脉注射FA 100 mg镇痛，同时复合SF静脉自控镇痛，可降低结直肠肿瘤切除患者术后促炎因子的表达，同时提高抗炎因子水平，并促进患者术后免疫功能的恢复。
목적：탐토불동시간급여불비락분지（ FA）주사액대결직장종류절제술환자술후혈장염성인자표체적영향。방법선택택기결직장종류절제술환자40례，수궤분위2조，매조20례。A조：수술개피전30 min급여FA 100 mg；B조：수술개피후30 min급여FA 100 mg。술후균행서분태니（ SF）정맥자공진통（ PCIA）。비교2조술전급술후6 h、24 h혈장백개소-2（IL-2）、백개소-6（ IL-6）、백개소-10（IL-10）、종류배사인자（TNF-α）、거서세포-집락자격인자（ M-CSF）적농도。결과여치료전비교，2조술후6 h、24 h IL-2수평균강저，이IL-6화IL-10수평균승고（ P ＜0．01）；여B조비교，A조술후6 h、24 h시IL-2승고， IL-6강저（ P균＜0．05）；여B조비교，A조술후6 h IL-10수평승고（ P ＜0．05）。2조환자각시간점TNF-α화M-CSF수평차이균무통계학의의（ P﹥0．05）。결론수술전정맥주사FA 100 mg진통，동시복합SF정맥자공진통，가강저결직장종류절제환자술후촉염인자적표체，동시제고항염인자수평，병촉진환자술후면역공능적회복。
Objective To explore the different time to administrate the flurbiprofen axetil ( FA) injection effects on the expression of plasma inflammatory cytokines in colorectal tumor resection patients .Methods Selected elective colorectal cancer resection patients ( n =40 ) , they were randomly divided into 2 groups , 20 patients in each group .Group A: open skin before operation for 30 min FA 100 mg; group B: after operation skin for 30 min FA 100 mg.Postoperative sufentanil (SF) were performed in patient controlled intravenous analgesia (PCIA).Comparison of 6 h, 24 h of plasma interleukin 2 (IL-2), interleukin 6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor (TNF-α), macrophage-colony stimulating factor ( M-CSF) concentration between the 2 groups before and after the operation .Results Compared with before treatment , the 2 groups'IL 2 levels after 6 h, 24 h were lower, while IL-6 and IL-10 levels were elevated ( P <0.01);compared with group B, after 6 h, 24 h, group A's IL-2 increased, IL-6 reduced ( P <0.05);and compared with group B, after operation for 6h, group A's IL-10 levels was increased ( P <0.05).Patients in the 2 groups at each time point, TNF-αand M-CSF levels showed no statistically significant differences ( P >0.05).Conclusion Intravenous injection of FA 100 mg before operation, and com-bined with patient-controlled intravenous SF analgesia can reduce the expression of inflammatory factor on colorectal tumor pa -tients, while improving the anti-inflammatory cytokines , and promote the recovery of immune function of postoperative patient .