CAJ | 학술논문

目的：观察自拟益气化瘀通络方对原发性肾病综合征激素维持治疗阶段患者凝血功能及血脂的影响。方法将50例已确诊的原发性肾病综合征在激素维持治疗阶段的患者随机分为2组，治疗组25例给予益气化瘀通络中药联合激素治疗，对照组25例给予单纯激素治疗，2组连续治疗1个月，观察血凝、血脂指标和血尿蛋白指标。结果治疗组治疗前后比较在降低血浆纤维蛋白原（ Fib）、升高抗凝血酶III（ AT-III），降低血清总胆固醇（ TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）和减少24 h尿蛋白（24 h-UP）、升高血白蛋白（Alb）方面有显著性差异（ P ＜0．01）；而对照组治疗后各项指标均无显著改善。治疗组治疗后与对照组治疗后比较在降低血浆Fib、升高AT-Ⅲ，降低血清TC、TG和减少24 h-UP方面疗效更为显著（ P ＜0．05或P ＜0．01）。结论自拟益气化瘀通络方可以明显改善原发性肾病综合征激素维持治疗阶段患者的血液高凝状态和脂代谢紊乱。
목적：관찰자의익기화어통락방대원발성신병종합정격소유지치료계단환자응혈공능급혈지적영향。방법장50례이학진적원발성신병종합정재격소유지치료계단적환자수궤분위2조，치료조25례급여익기화어통락중약연합격소치료，대조조25례급여단순격소치료，2조련속치료1개월，관찰혈응、혈지지표화혈뇨단백지표。결과치료조치료전후비교재강저혈장섬유단백원（ Fib）、승고항응혈매III（ AT-III），강저혈청총담고순（ TC）、삼선감유（TG）、저밀도지단백담고순（LDL-C）화감소24 h뇨단백（24 h-UP）、승고혈백단백（Alb）방면유현저성차이（ P ＜0．01）；이대조조치료후각항지표균무현저개선。치료조치료후여대조조치료후비교재강저혈장Fib、승고AT-Ⅲ，강저혈청TC、TG화감소24 h-UP방면료효경위현저（ P ＜0．05혹P ＜0．01）。결론자의익기화어통락방가이명현개선원발성신병종합정격소유지치료계단환자적혈액고응상태화지대사문란。
Objective To observe the effect of Yiqihuayutongluo decoction on primary nephrotic syndrome hormone maintain influence treatment and coagulation function in patients with blood lipid phase .Methods Fifty patients who had been diagnosed with primary nephrotic syndrome and received maintained treatment of hormone were randomly divided into two groups, 25 cases in the treatment group were given Yiqihuayutongluo decoction combined hormone therapy , 25 cases in the control group were treated with hormone therapy , 2 groups received 1 months of continuous treatment , and then observe blood coagulation , blood lipid and blood and urine protein index .Results In treatment group , compared before and after treatment , it has significant difference in reducing plasma fibrinogen (Fib), increase of antithrombin III (AT-III), lower serum total cholesterol (TC), triglyceride (three TG), low density lipoprotein cholesterol (LDL-C) and reduce 24h urine protein (24h UP), elevated serum albumin (Alb) ( P <0.01); while the control group after treatment , all indexes were not significant improvement .Treatment group and control group after treatment , treatment group has more significant effect in reducing plas-ma Fib, increased AT-III, reduce serum TC, TG and reduce 24 h UP ( P <0.05 or P <0.01).Conclusion It proved that the Yiqihuayutongluo decoction could obviously improve the blood hypercoagulability and disorders of lipid metabolism in pa -tients with the primary nephrotic syndrome in treatment of hormone maintain stage .