物理化学学报
物理化學學報
물이화학학보
ACTA PHYSICO-CHIMICA SINICA
2014年
7期
1363-1369
,共7页
王新环%韩秋森%李婧影%杨蓉%刁国旺%王琛
王新環%韓鞦森%李婧影%楊蓉%刁國旺%王琛
왕신배%한추삼%리청영%양용%조국왕%왕침
纳米金棒%等离子共振吸收%生物相容性%表面修饰%热疗
納米金棒%等離子共振吸收%生物相容性%錶麵脩飾%熱療
납미금봉%등리자공진흡수%생물상용성%표면수식%열료
Gold nanorod%Plasmon resonance absorption%Biocompatibility%Surface functionalization%Hyperthermia
采用简便快捷的无种子法一步完成了纳米金棒的制备。通过改变实验条件可以调控纳米金棒的吸收峰从可见到近红外转移。将巯基聚乙二醇(PEG-SH)置换金棒表面的十六烷基三甲基溴化铵(CTAB)分子,大大提高了金棒的生物相容性。制备的纳米金棒在近红外(NIR)光照射下对肿瘤细胞有很好的杀伤效果。研究结果为纳米金棒用于抗肿瘤治疗提供了实验基础。
採用簡便快捷的無種子法一步完成瞭納米金棒的製備。通過改變實驗條件可以調控納米金棒的吸收峰從可見到近紅外轉移。將巰基聚乙二醇(PEG-SH)置換金棒錶麵的十六烷基三甲基溴化銨(CTAB)分子,大大提高瞭金棒的生物相容性。製備的納米金棒在近紅外(NIR)光照射下對腫瘤細胞有很好的殺傷效果。研究結果為納米金棒用于抗腫瘤治療提供瞭實驗基礎。
채용간편쾌첩적무충자법일보완성료납미금봉적제비。통과개변실험조건가이조공납미금봉적흡수봉종가견도근홍외전이。장구기취을이순(PEG-SH)치환금봉표면적십륙완기삼갑기추화안(CTAB)분자,대대제고료금봉적생물상용성。제비적납미금봉재근홍외(NIR)광조사하대종류세포유흔호적살상효과。연구결과위납미금봉용우항종류치료제공료실험기출。
We report the synthesis of gold nanorods with a simple and efficient seedless method. By changing the experimental conditions, the longitudinal absorption peak of the gold nanorods can be shifted from the visible to the near-infrared region. Mercaptopolyethylene glycol (PEG-SH) was then used to substitute cetyltrimethyl ammonium bromide (CTAB) to improve the biocompatibility of the gold nanorods. A strong inhibition of cancer cellgrowth was observed with the modified gold nanorods under near-infrared (NIR) light irradiation. Our results wil be helpful for the potential applications of gold nanorods in clinical photo-thermal cancer therapy.