CAJ | 학술논문

目的：观察高压氧联合补阳还五汤治疗急性脑梗死认知功能障碍的临床疗效及安全性。方法将120例急性脑梗死认知功能障碍患者随机分为2组。对照组60例接受高压氧治疗，治疗组60例在对照组治疗基础上予补阳还五汤治疗。2组10 d为1个疗程，2个疗程后统计疗效，并应用简易智能精神状态量表（MMSE）、日常生活活动量评分（ADL）及美国国立卫生研究院卒中量表（NIHSS）分别观察2组治疗前后认知功能、生活自理情况及神经功能缺损程度，观察2组治疗前后血液流变学指标变化。结果治疗组疗效优于对照组（P＜0．05）；2组治疗后比较，治疗组MMSE、ADL评分均高于对照组（P＜0．05），治疗组NIHSS评分低于对照组（P＜0．05）；治疗组血浆黏度、纤维蛋白原低于对照组（P＜0．05），治疗组凝血酶原时间、凝血酶时间及部分凝血活酶时间长于对照组（P＜0．05）。结论高压氧联合补阳还五汤可有效改善急性脑梗死认知功能障碍患者脑部缺血性损害状态，从而有助于其认知功能的恢复，对改善患者日常生活功能具有重要意义，且安全性良好，无明显毒副作用。
목적：관찰고압양연합보양환오탕치료급성뇌경사인지공능장애적림상료효급안전성。방법장120례급성뇌경사인지공능장애환자수궤분위2조。대조조60례접수고압양치료，치료조60례재대조조치료기출상여보양환오탕치료。2조10 d위1개료정，2개료정후통계료효，병응용간역지능정신상태량표（MMSE）、일상생활활동량평분（ADL）급미국국립위생연구원졸중량표（NIHSS）분별관찰2조치료전후인지공능、생활자리정황급신경공능결손정도，관찰2조치료전후혈액류변학지표변화。결과치료조료효우우대조조（P＜0．05）；2조치료후비교，치료조MMSE、ADL평분균고우대조조（P＜0．05），치료조NIHSS평분저우대조조（P＜0．05）；치료조혈장점도、섬유단백원저우대조조（P＜0．05），치료조응혈매원시간、응혈매시간급부분응혈활매시간장우대조조（P＜0．05）。결론고압양연합보양환오탕가유효개선급성뇌경사인지공능장애환자뇌부결혈성손해상태，종이유조우기인지공능적회복，대개선환자일상생활공능구유중요의의，차안전성량호，무명현독부작용。
Objective To observe the clinical efficacy and safety of hyperbaric oxygen combined with Buy-ang Huanwu decoction on the treatment of cognitive impairment in patients with acute cerebral infarction .Methods 120 acute cerebral infarction patients with cognitive impairment were randomly divided into treatment group and con -trol group.60 cases in control group were treated by hyperbaric oxygen therapy , 60 cases of the treatment group receivedhyperbaric oxygen combined with Buyang Huanwu decoction treatment , After two courses the clinical efficacyof two groups were compared by MMSE, ADL and NIHSS.Results The total effective rate of treatment group is sig -nificantly higher than the control group .After treatment MMSE, ADL score in the treatment group was significantlyhigher than the control group, the NIHSS score was significantly lower than that of the latter (P <0.05); after treatment,the treatment group plasma viscosity, fibrinogen was significantly lower than that of the control group , the prothrombintime, thrombin time and activated partial thromboplastin time was significantly higher than the latter .Conclusion Hyperbaric oxygen combined with Buyang Huanwu decoction can effectively improve the cognitive impair -ment in acute cerebral infarction patients ischemic brain damage state , so as to contribute to the recovery of cognitivefunction, and has important significance to improve the ability of daily life of patients , and good security, no obviousside effect, is worthy of clinical application.