CAJ | 학술논문

目的：观察菖蒲芪丹汤对扩张型心肌病患者的影响。方法将90例扩张型心肌病患者随机分为2组。对照组45例予西医常规治疗，治疗组45例在对照组治疗基础上加菖蒲芪丹汤，连续应用2个月。检测2组治疗前后心率、呼吸频率、血压、24 h尿量、心胸比例、左室舒张末期内径（ LVEDD ）、左室收缩末期内径（ LVESD）、左室射血分数（ LVEF）及血浆B型脑钠肽（ BNP）浓度变化。结果治疗组总有效率高于对照组（P＜0．05）。2组治疗后心率、呼吸频率、心胸比例、LVEDD、LVESD、LVEF、收缩压、舒张压及BNP均较本组治疗前明显下降（P＜0．01，P ＜0．05），24 h尿量升高（P＜0．01，P＜0．05）；且2组治疗后心率、呼吸频率、24 h尿量、心胸比例、LVEDD 、LVESD、LVEF及BNP组间比较差异有统计学意义（P＜0．01，P＜0．05）。结论菖蒲芪丹汤能明显改善扩张型心肌病患者心功能，用药安全，临床效果显著。
목적：관찰창포기단탕대확장형심기병환자적영향。방법장90례확장형심기병환자수궤분위2조。대조조45례여서의상규치료，치료조45례재대조조치료기출상가창포기단탕，련속응용2개월。검측2조치료전후심솔、호흡빈솔、혈압、24 h뇨량、심흉비례、좌실서장말기내경（ LVEDD ）、좌실수축말기내경（ LVESD）、좌실사혈분수（ LVEF）급혈장B형뇌납태（ BNP）농도변화。결과치료조총유효솔고우대조조（P＜0．05）。2조치료후심솔、호흡빈솔、심흉비례、LVEDD、LVESD、LVEF、수축압、서장압급BNP균교본조치료전명현하강（P＜0．01，P ＜0．05），24 h뇨량승고（P＜0．01，P＜0．05）；차2조치료후심솔、호흡빈솔、24 h뇨량、심흉비례、LVEDD 、LVESD、LVEF급BNP조간비교차이유통계학의의（P＜0．01，P＜0．05）。결론창포기단탕능명현개선확장형심기병환자심공능，용약안전，림상효과현저。
Objective To observe the effect of dilated cardiomyopathy treated by Changpu Qidan decoction . Methods 90 cases of dilated cardiomyopathy were randomly divided into two groups .Patients in control group ( n=45) were treated by conventional western medicine therapy .Patients in treatment group (n=45) were treated by Changpu Qidan decoction on the basis of control group treatment .The course was two months in two groups .The changes of heart rate , respiratory rate , blood pressure , 24 h urine volume , cardiothoracic ratio , left ventricular end-diastolic diameter (LVEDD), left ventricular systolic diameter (LVESD), left ventricular ejection fraction (LVEF) and plasma B-type natriuretic peptide ( BNP ) concentration before and after treatment were detected .Results The total effective rate in treatment group was higher than that in control group (P<0.05).Heart rate, respiratory rate, cardiothoracic ratio , LVEDD, LVESD, LVEF, systolic blood pressure , diastolic blood pressure and BNP con-centration after treatment were significantly decreased in two groups (P<0.01, P<00.5). 24 h urine volume was increased after treatment (P<0.01, P<0.05).There were significant difference between two groups on heart rate , respiratory rate, 24 h urine volume, cardiothoracic ratio, LVEDD, LVESD, LVEF and BNP concentration (P <0.01, P<0.05).Conclusion Changpu Qidan decoction can significantly improve heart function in patients with dilated cardiomyopathy , medication safety , and significant clinical effect .