CAJ | 학술논문

目的：探讨C-反应蛋白（CPR）与糖尿病肾脏微血管病变的相关性。方法92例糖尿病肾病患者按照Mogensen标准分为正常白蛋白尿组34例，微量白蛋白尿组32例，大量白蛋白尿组24例，并且选择同期来我院进行监控体检的正常对照组30例为对照组，对所有研究对象血清CPR进行检测分析。结果 CRP等指标大量蛋白尿组水平明显高于其他三组的水平，微量蛋白尿组明显高于正常蛋白尿组和对照组水平，差异均有显著的统计学意义（P＜0.01），并且CRP与尿白蛋白的排泄率（UEA）呈显著的正相关（r=0.768， P＜0.01）。结论 C-反应蛋白与糖尿病肾病微血管病变密切相关，是一种反映早期糖尿病肾损害的理想的标志物。
목적：탐토C-반응단백（CPR）여당뇨병신장미혈관병변적상관성。방법92례당뇨병신병환자안조Mogensen표준분위정상백단백뇨조34례，미량백단백뇨조32례，대량백단백뇨조24례，병차선택동기래아원진행감공체검적정상대조조30례위대조조，대소유연구대상혈청CPR진행검측분석。결과 CRP등지표대량단백뇨조수평명현고우기타삼조적수평，미량단백뇨조명현고우정상단백뇨조화대조조수평，차이균유현저적통계학의의（P＜0.01），병차CRP여뇨백단백적배설솔（UEA）정현저적정상관（r=0.768， P＜0.01）。결론 C-반응단백여당뇨병신병미혈관병변밀절상관，시일충반영조기당뇨병신손해적이상적표지물。
Objective To explore the association between C-reactive protein(CPR) and renal microvascular disease in diabetic.Methods 92 patients with diabetic nephropathy were divided into normal albuminuria group(n=34), microalbuminuria group(n=32), macroalbuminuria group(n=24) according the Mogensen standards. 30 normal cases were selected as control group. The level of serum CPR were detected.Results The level of serum CPR in massive proteinuria group were higher than that in other three groups. The differences were statistically significant(P<0.01). The level of serum CPR in microalbuminuria group were significantly higher than that in normal albuminuria group and the control group. The differences were statistically significant(P<0.01). There were positive correlation between the level of serum CPR and urinary albumin excretion Rate(UAE)(r=0.768,P<0.01).ConclusionThe level of serum CPR is closely related with microvascular lesions of diabetic nephropathy, which is a markers ideal of early diabetic renal damage.