CAJ | 학술논문

目的：探讨研究全胃切除空肠 P 袢代胃术治疗胃底贲门癌的临床疗效研究。方法将符合标准的65例胃底贲门癌患者，随机分成观察组33例与对照组32例，观察组患者使用全胃切除空肠P袢代胃术进行治疗，对照组患者采用常规近侧胃切除术进行治疗。比较观察组与对照组的疗效、生存率与不良反应发生情况。结果两组患者在手术时间、术中出血量、切口愈合时间以及住院时间上没有统计学差异（P＞0.05）。观察组患者3个月、6个月与12个月的胃排空时间与每次饮食量均显著高于对照组（P＜0.05）；观察组患者3个月与6个月每日饮食次数显著低于对照组（P＜0.05）。观察组患者3年生存率为66.7%，显著高于对照组的40.6%（P＜0.05）。观察组患者胃排空障碍发生率与不良反应总发生率分别为0.0%与9.1%，均显著低于对照组的15.6%与31.3%（P＜0.05）。结论全胃切除空肠 P 袢代胃术治疗胃底贲门癌能够有效地提高患者的生存率与生活质量，减少不良反应的发生，具有较好的临床意义，值得在临床上推广使用。
목적：탐토연구전위절제공장 P 번대위술치료위저분문암적림상료효연구。방법장부합표준적65례위저분문암환자，수궤분성관찰조33례여대조조32례，관찰조환자사용전위절제공장P번대위술진행치료，대조조환자채용상규근측위절제술진행치료。비교관찰조여대조조적료효、생존솔여불량반응발생정황。결과량조환자재수술시간、술중출혈량、절구유합시간이급주원시간상몰유통계학차이（P＞0.05）。관찰조환자3개월、6개월여12개월적위배공시간여매차음식량균현저고우대조조（P＜0.05）；관찰조환자3개월여6개월매일음식차수현저저우대조조（P＜0.05）。관찰조환자3년생존솔위66.7%，현저고우대조조적40.6%（P＜0.05）。관찰조환자위배공장애발생솔여불량반응총발생솔분별위0.0%여9.1%，균현저저우대조조적15.6%여31.3%（P＜0.05）。결론전위절제공장 P 번대위술치료위저분문암능구유효지제고환자적생존솔여생활질량，감소불량반응적발생，구유교호적림상의의，치득재림상상추엄사용。
Objective To integrative clinical efficacy of total gastrectomy stomach surgery on behalf of jejunal loop P for gastric cardia cancer. Methods 65 patients with this disease were randomly divided into observed group (33 cases) and control group (32 cases). Patients in observed group received the treatment of total gastrectomy stomach surgery on behalf of jejunal loop P, while others received the treatment of near side gastrectomy. The curative effect, survival rate and complications of the two groups were compared. Results There was no significant difference in operation time, intraoperative blood loss, incision healing time and hospital stay time between the two groups (P>0.05). 3, 6 and 12 months after the treatment, the gastric emptying time and quantity of each diet in observed group were significantly higher than that of the control group (P<0.05). 3 and 6 months after the treatment, the times of daily diet in observed group was significantly lower than that of the control group (P<0.05). The three year survival rate in observed group was 66.7%, which was significantly higher than that of the control group which was 40.6%(P<0.05). The rates of gastric emptying rate and total complications in observed group were 0.0%and 9.1%, which were significantly lower than that of the control group which were 15.6%and 31.3%(P<0.05). Conclusion Total gastrectomy stomach surgery on behalf of jejunal loop P can improve the survival rate and quality of life, and reduce the occurrence of complications. It is worthy of clinical promotion.