CAJ | 학술논문

支气管哮喘(哮喘)在儿童中发病率日趋增高,越来越多的研究发现表观遗传学在哮喘发病中起重要作用,其中最重要的即为组蛋白乙酰化与去乙酰化修饰,分别由组蛋白乙酰基转移酶(HAT)和组蛋白去乙酰基酶(HDAC)所催化,通过引起Th1/Th2失衡、增加气道高反应性、调节各种炎症介质等介导哮喘发病.该文综述HAT和HDAC介导哮喘发病的最新及其他可能机制、糖皮质激素治疗儿童哮喘的表观学机制,以期能指导从组蛋白乙酰化作为切入点.
지기관효천(효천)재인동중발병솔일추증고,월래월다적연구발현표관유전학재효천발병중기중요작용,기중최중요적즉위조단백을선화여거을선화수식,분별유조단백을선기전이매(HAT)화조단백거을선기매(HDAC)소최화,통과인기Th1/Th2실형、증가기도고반응성、조절각충염증개질등개도효천발병.해문종술HAT화HDAC개도효천발병적최신급기타가능궤제、당피질격소치료인동효천적표관학궤제,이기능지도종조단백을선화작위절입점.
The incidence of bronchial asthma in children is increasing nowadays.More and more studies have showed that epigenetics plays an important role in the pathogenesis of asthma.One of them are histone modification(acetylation and deacetylation),which is catalyzed by histone acetyltransferase (HAT) and histone deacetylase (HDAC).HAT and HDAC can mediate asthma via causing Th1/Th2 imbalance,increased airway hyperresponsiveness,regulation of various inflammatory medium and so on.This paper reviews the HAT and HDAC mediated incidence of asthma and other possible mechanisms,the latest of glucocorticoid in the treatment of children with asthma epigenetic mechanisms.