CAJ | 학술논문

观察准分子激光角膜原位磨镶术（LASIK）前、后角膜知觉、泪膜功能、结膜杯状细胞情况，初步探讨LASIK术后干眼症情况。方法90例180眼行LASIK近视患者分别于术前，术后1周，术后1、3、6个月行基础泪液分泌试验（Sit）、泪膜破裂时间（BUT）测定、角膜知觉检查、角结膜荧光素钠染色检查及术前，术后1、3、6个月行结膜印迹细胞学检查。结果 Sit值术后各期均较术前减少，但差异无统计学意义（P＞0．05）；术后1周，术后1、3个月BUT值较术前明显缩短，差异有统计学意义（P＜0．05），角膜知觉较术前明显下降，差异有统计学意义（P＜0．01），均于术后6个月恢复，术后各期角结膜荧光素钠染色与术前比较差异均无统计学意义（P＞0．05），术后1、3个月结膜上皮鳞状化生程度较术前明显加重，差异有统计学意义（P＜0．01），6个月后恢复。结论 LASIK术后会出现不同程度的泪膜稳定性下降、角膜知觉减退、眼表组织损害，但随时间延长会逐渐恢复。
관찰준분자격광각막원위마양술（LASIK）전、후각막지각、루막공능、결막배상세포정황，초보탐토LASIK술후간안증정황。방법90례180안행LASIK근시환자분별우술전，술후1주，술후1、3、6개월행기출루액분비시험（Sit）、루막파렬시간（BUT）측정、각막지각검사、각결막형광소납염색검사급술전，술후1、3、6개월행결막인적세포학검사。결과 Sit치술후각기균교술전감소，단차이무통계학의의（P＞0．05）；술후1주，술후1、3개월BUT치교술전명현축단，차이유통계학의의（P＜0．05），각막지각교술전명현하강，차이유통계학의의（P＜0．01），균우술후6개월회복，술후각기각결막형광소납염색여술전비교차이균무통계학의의（P＞0．05），술후1、3개월결막상피린상화생정도교술전명현가중，차이유통계학의의（P＜0．01），6개월후회복。결론 LASIK술후회출현불동정도적루막은정성하강、각막지각감퇴、안표조직손해，단수시간연장회축점회복。
Objective To investigate symptoms of xerophthalmia after laser assisted in‐situ keratomi leusis (LASIK) .Methods LASIK was performed in 180 eyes of 90 patients .Schirmer Ⅰ test (Sit) ,detection of breakup time of tear film (BUT) ,corneal sensitivity ,corneal and conjunctiva sodium fluorescein were performed before and 1 week ,1 ,3 and 6 months after LASIK therapy ,and conjunctival impression cytology detection was performed 1 ,3 and 6 months after therapy .Results After LASIK therapy ,Sit value decreased ,but the difference was not significant (P>0 .05) .BUT and corneal sensitivity decreased at 1 week ,1 and 3 months after therapy (P<0 .05) ,but recovered at 6 months after therapy .Sodium fluorescein were without statistical difference at all time (P>0 .05) .Impression cytology had significant damage at 1 and 3 months after therapy (P<0 .05) ,but recovered at 6 months .Conclusion LASIK could break down tear‐film stability ,decrease corneal sensitivity ,damage oculo‐surface tissue ,but all of these symptoms could be recovered gradually .